YRC Public Data Repository - Protein Structure Prediction

Protein:	CFLAR
Organism:	Homo sapiens
Length:	480 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CFLAR.

Description	E-value	Query Range	Subject Range
gi\|61372984, gi\|... - gi\|61372984\|gb\|AAX43950.1\| CASP8 and FADD-like apoptosis regulator [synthetic construct], gi\|3058475...	0.0	[1..480]	[1..480]
gi\|2653416, gi\|2... - gi\|2653416\|emb\|CAA74366.1\| CASH alpha protein [Homo sapiens], gi\|21361769\|ref\|NP_003870.3\| CASP8 and...	0.0	[1..480]	[1..480]
gi\|114582575, gi... - gi\|114582581\|ref\|XP_001171850.1\| PREDICTED: CASP8 and FADD-like apoptosis regulator isoform 12 [Pan ...	0.0	[1..480]	[1..480]
CFLAR_PONPY - CASP8 and FADD-like apoptosis regulator precursor [Contains: CASP8 and FADD-like apoptosis regulator... CFLAR_PONAB - CASP8 and FADD-like apoptosis regulator OS=Pongo abelii GN=CFLAR PE=2 SV=1	0.0	[1..480]	[1..480]

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Predicted Domain #1

Region A:
Residues: [1-194]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY  60
   61 RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM 120
  121 GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT 180
  181 SYRNVLQAAI QKSL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	34.0
Match:	2bbzA
Description:	Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP Inhibition
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [195-480]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDPSNNFRLH NGRSKEQRLK EQLGAQQEPV KKSIQESEAF LPQSIPEERY KMKSKPLGIC  60
   61 LIIDCIGNET ELLRDTFTSL GYEVQKFLHL SMHGISQILG QFACMPEHRD YDSFVCVLVS 120
  121 RGGSQSVYGV DQTHSGLPLH HIRRMFMGDS CPYLAGKPKM FFIQNYVVSE GQLEDSSLLE 180
  181 VDGPAMKNVE FKAQKRGLCT VHREADFFWS LCTADMSLLE QSHSSPSLYL QCLSQKLRQE 240
  241 RKRPLLDLHI ELNGYMYDWN SRVSAKEKYY VWLQHTLRKK LILSYT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	76.045757
Match:	1cp3A
Description:	Apopain (caspase-3, cpp32)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
peptidase activity	3.07648676430905	bayes_pls_golite062009
protein binding	2.96725373477762	bayes_pls_golite062009
binding	2.91261616137775	bayes_pls_golite062009
hydrolase activity	2.68442077801437	bayes_pls_golite062009
endopeptidase activity	2.49877323830478	bayes_pls_golite062009
cysteine-type peptidase activity	2.37850336421322	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	1.92144732327593	bayes_pls_golite062009
cysteine-type endopeptidase activity	1.82979469421101	bayes_pls_golite062009
apoptotic protease activator activity	1.68590402463614	bayes_pls_golite062009
catalytic activity	1.03907950272772	bayes_pls_golite062009
enzyme regulator activity	0.0737251792690711	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: