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Protein Overview: CFLAR

General Information:
Name(s) found: CFLAR [HGNC (HUGO)]
Description(s) found:
Found 50 descriptions.
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  • CASP8 and FADD-like apoptosis regulator [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 480 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSAEVIHQVE EALDTDEKEM LLFLCRDVAI DVVPPNVRDL LDILRERGKL SVGDLAELLY  60
   61 RVRRFDLLKR ILKMDRKAVE THLLRNPHLV SDYRVLMAEI GEDLDKSDVS SLIFLMKDYM 120
  121 GRGKISKEKS FLDLVVELEK LNLVAPDQLD LLEKCLKNIH RIDLKTKIQK YKQSVQGAGT 180
  181 SYRNVLQAAI QKSLKDPSNN FRLHNGRSKE QRLKEQLGAQ QEPVKKSIQE SEAFLPQSIP 240
  241 EERYKMKSKP LGICLIIDCI GNETELLRDT FTSLGYEVQK FLHLSMHGIS QILGQFACMP 300
  301 EHRDYDSFVC VLVSRGGSQS VYGVDQTHSG LPLHHIRRMF MGDSCPYLAG KPKMFFIQNY 360
  361 VVSEGQLEDS SLLEVDGPAM KNVEFKAQKR GLCTVHREAD FFWSLCTADM SLLEQSHSSP 420
  421 SLYLQCLSQK LRQERKRPLL DLHIELNGYM YDWNSRVSAK EKYYVWLQHT LRKKLILSYT 480
  481

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..194] PSI-BLAST 34.0 Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP Inhibition
    2 View Details [195..480] PSI-BLAST 76.045757 Apopain (caspase-3, cpp32)

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • peptidase activity
    		•  3.07648676430905 bayes_pls_golite062009
  • protein binding
    		•  2.96725373477762 bayes_pls_golite062009
  • binding
    		•  2.91261616137775 bayes_pls_golite062009
  • hydrolase activity
    		•  2.68442077801437 bayes_pls_golite062009
  • endopeptidase activity
    		•  2.49877323830478 bayes_pls_golite062009
  • cysteine-type peptidase activity
    		•  2.37850336421322 bayes_pls_golite062009
  • peptidase activity, acting on L-amino acid peptides
    		•  1.92144732327593 bayes_pls_golite062009
  • cysteine-type endopeptidase activity
    		•  1.82979469421101 bayes_pls_golite062009
  • apoptotic protease activator activity
    		•  1.68590402463614 bayes_pls_golite062009
  • catalytic activity
    		•  1.03907950272772 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.0737251792690711 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle