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Protein Overview: ACTA2

General Information:
Name(s) found: ACTA2 [HGNC (HUGO)]
Description(s) found:
Found 46 descriptions.
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  • actin, alpha 2, smooth muscle, aorta [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 377 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCEEEDSTAL VCDNGSGLCK AGFAGDDAPR AVFPSIVGRP RHQGVMVGMG QKDSYVGDEA  60
   61 QSKRGILTLK YPIEHGIITN WDDMEKIWHH SFYNELRVAP EEHPTLLTEA PLNPKANREK 120
  121 MTQIMFETFN VPAMYVAIQA VLSLYASGRT TGIVLDSGDG VTHNVPIYEG YALPHAIMRL 180
  181 DLAGRDLTDY LMKILTERGY SFVTTAEREI VRDIKEKLCY VALDFENEMA TAASSSSLEK 240
  241 SYELPDGQVI TIGNERFRCP ETLFQPSFIG MESAGIHETT YNSIMKCDID IRKDLYANNV 300
  301 LSGGTTMYPG IADRMQKEIT ALAPSTMKIK IIAPPERKYS VWIGGSILAS LSTFQQMWIS 360
  361 KQEYDEAGPS IVHRKCF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run None Entered Sample pIC145 from april 2005 Okada, M., et al. (2006)
    View Run None Entered Sample pIC146 from april 2005 Okada, M., et al. (2006)
    View Run gi|14317902, gi|... No Comments Cheeseman, I.M., et al. (2004)
    View Run MIS12 No Comments Cheeseman, I.M., et al. (2004)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..377] PSI-BLAST 146.0 Actin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • lysine N-acetyltransferase activity
    		•  6.00435371802752 bayes_pls_golite062009
  • histone acetyltransferase activity
    		•  6.00435371802752 bayes_pls_golite062009
  • ATP-dependent 5'-3' DNA helicase activity
    		•  4.48403442393358 bayes_pls_golite062009
  • 5'-3' DNA helicase activity
    		•  4.48403442393358 bayes_pls_golite062009
  • N-acetyltransferase activity
    		•  4.4623239863508 bayes_pls_golite062009
  • N-acyltransferase activity
    		•  4.17753709537507 bayes_pls_golite062009
  • acetyltransferase activity
    		•  3.85999832240402 bayes_pls_golite062009
  • actin binding
    		•  3.49917339467744 bayes_pls_golite062009
  • DNA helicase activity
    		•  3.48040623488385 bayes_pls_golite062009
  • acyltransferase activity
    		•  3.31611368687679 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  3.27955167799398 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  3.14961582364442 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  3.11425505645918 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  3.10494259200141 bayes_pls_golite062009
  • myosin binding
    		•  2.53108346927043 bayes_pls_golite062009
  • kinase activity
    		•  2.39470546929151 bayes_pls_golite062009
  • structural molecule activity
    		•  2.37892721989886 bayes_pls_golite062009
  • carbohydrate kinase activity
    		•  2.33338276303563 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  2.28750451001371 bayes_pls_golite062009
  • ADP binding
    		•  2.25399944386472 bayes_pls_golite062009
  • binding
    		•  2.11855816699924 bayes_pls_golite062009
  • transcription regulator activity
    		•  2.09111975841662 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  2.06985477154666 bayes_pls_golite062009
  • actin filament binding
    		•  2.01821925799878 bayes_pls_golite062009
  • protein binding
    		•  2.00711904074672 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.84294882554466 bayes_pls_golite062009
  • hexokinase activity
    		•  1.70516840340504 bayes_pls_golite062009
  • DNA binding
    		•  1.70014394990425 bayes_pls_golite062009
  • transcription activator activity
    		•  1.35676801272576 bayes_pls_golite062009
  • transporter activity
    		•  1.2883466875237 bayes_pls_golite062009
  • transferase activity
    		•  1.25544026047211 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  1.19428728049016 bayes_pls_golite062009
  • transcription factor activity
    		•  1.06678984888387 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.900931843471417 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.898645342556399 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.875671218597808 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.866917783590327 bayes_pls_golite062009
  • glucose binding
    		•  0.81023419099138 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.796517590178929 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.78242344952806 bayes_pls_golite062009
  • protein transporter activity
    		•  0.780308299678282 bayes_pls_golite062009
  • ATPase activity
    		•  0.687771333492666 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.574998559133169 bayes_pls_golite062009
  • glucokinase activity
    		•  0.47468456642723 bayes_pls_golite062009
  • protein kinase activity
    		•  0.344796257628435 bayes_pls_golite062009
  • nucleosome binding
    		•  0.329990231856661 bayes_pls_golite062009
  • catalytic activity
    		•  0.296484721581333 bayes_pls_golite062009
  • glucuronosyltransferase activity
    		•  0.281824450653963 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.166787445046116 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.162883291947849 bayes_pls_golite062009
  • ATP binding
    		•  0.13613543261671 bayes_pls_golite062009
  • ligase activity
    		•  0.106704967795667 bayes_pls_golite062009
  • adenyl ribonucleotide binding
    		•  0.0977998908064818 bayes_pls_golite062009
  • chromatin binding
    		•  0.0489277194984092 bayes_pls_golite062009
  • unfolded protein binding
    		•  0.0304569608189402 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.77

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle