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Protein Overview: XRCC6

General Information:
Name(s) found: XRCC6 [HGNC (HUGO)]
Description(s) found:
Found 59 descriptions.
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  • X-ray repair complementing defective repair in Chinese hamster cells 6 [HGNC (HUGO)]
    • Organism: Homo sapiens
    Length: 609 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSGWESYYKT EGDEEAEEEQ EENLEASGDY KYSGRDSLIF LVDASKAMFE SQSEDELTPF  60
   61 DMSIQCIQSV YISKIISSDR DLLAVVFYGT EKDKNSVNFK NIYVLQELDN PGAKRILELD 120
  121 QFKGQQGQKR FQDMMGHGSD YSLSEVLWVC ANLFSDVQFK MSHKRIMLFT NEDNPHGNDS 180
  181 AKASRARTKA GDLRDTGIFL DLMHLKKPGG FDISLFYRDI ISIAEDEDLR VHFEESSKLE 240
  241 DLLRKVRAKE TRKRALSRLK LKLNKDIVIS VGIYNLVQKA LKPPPIKLYR ETNEPVKTKT 300
  301 RTFNTSTGGL LLPSDTKRSQ IYGSRQIILE KEETEELKRF DDPGLMLMGF KPLVLLKKHH 360
  361 YLRPSLFVYP EESLVIGSST LFSALLIKCL EKEVAALCRY TPRRNIPPYF VALVPQEEEL 420
  421 DDQKIQVTPP GFQLVFLPFA DDKRKMPFTE KIMATPEQVG KMKAIVEKLR FTYRSDSFEN 480
  481 PVLQQHFRNL EALALDLMEP EQAVDLTLPK VEAMNKRLGS LVDEFKELVY PPDYNPEGKV 540
  541 TKRKHDNEGS GSKRPKVEYS EEELKTHISK GTLGKFTVPM LKEACRAYGL KSGLKKQELL 600
  601 EALTKHFQD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..609] PSI-BLAST 1000.0 DNA binding C-terminal domain of ku70; Ku70 subunit

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • double-stranded telomeric DNA binding
    		•  8.64621483095491 bayes_pls_golite062009
  • DNA-dependent protein kinase activity
    		•  7.33495559751688 bayes_pls_golite062009
  • telomeric DNA binding
    		•  5.16364366157397 bayes_pls_golite062009
  • transcription regulator activity
    		•  3.05720838352689 bayes_pls_golite062009
  • promoter binding
    		•  3.01492777192913 bayes_pls_golite062009
  • transcription activator activity
    		•  2.87080577911324 bayes_pls_golite062009
  • binding
    		•  2.75824485094584 bayes_pls_golite062009
  • protein binding
    		•  2.58357303743968 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.08531850924748 bayes_pls_golite062009
  • DNA binding
    		•  1.91667917801679 bayes_pls_golite062009
  • transcription factor activity
    		•  1.37299910766941 bayes_pls_golite062009
  • DNA-dependent ATPase activity
    		•  0.985753648509262 bayes_pls_golite062009
  • protein complex binding
    		•  0.94234534987624 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.914051610867509 bayes_pls_golite062009
  • single-stranded DNA binding
    		•  0.814975395718076 bayes_pls_golite062009
  • protein dimerization activity
    		•  0.73404855126602 bayes_pls_golite062009
  • DNA helicase activity
    		•  0.720743494912414 bayes_pls_golite062009
  • protein heterodimerization activity
    		•  0.64812784969409 bayes_pls_golite062009
  • ATP-dependent DNA helicase activity
    		•  0.506640285146188 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.450760554291027 bayes_pls_golite062009
  • structural molecule activity
    		•  0.375125487765613 bayes_pls_golite062009
  • receptor binding
    		•  0.234020194580985 bayes_pls_golite062009
  • transcription factor binding
    		•  0.184852480703492 bayes_pls_golite062009
  • protein C-terminus binding
    		•  0.15516806759612 bayes_pls_golite062009
  • identical protein binding
    		•  0.125363466534611 bayes_pls_golite062009
  • collagen binding
    		•  0.113837148027681 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.0660601071978013 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle