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Protein Overview: MSF1

General Information:
Name(s) found: MSF1 / YPR047W [SGD]
Description(s) found:
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  • gi|37362703|ref|NP_015372.2| Mitochondrial phenylalanyl-tRNA synthetase alpha subunit, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-t [NCBI NR]
  • gi|114152885|sp|P08425.3|SYFM_YEAST RecName: Full=Phenylalanyl-tRNA synthetase, mitochondrial; AltName: Full=Phenylalanine--tRNA ligase; Short=PheRS; Flags: Precursor [NCBI NR]
  • Phenylalanyl-tRNA synthetase, mitochondrial OS=Saccharomyces cerevisiae GN=MSF1 PE=1 SV=3 [Swiss-Prot]
  • MSF1 Phenylalanine--tRNA ligase alpha chain, mitochondrial [mips]
  • Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase [SGD]
  • Chr XVI from 657524-658933 [hmr_yeast5_DM3-1_pombe.fasta]
  • MSF1 SGDID:S0006251, Chr XVI from 657524-658933, Verified ORF [yeastflysequest.fasta]
  • MSF1 SGDID:S0006251, Chr XVI from 657526-658935, Verified ORF [10112005cervSGD.fasta]
  • Mitochondrial phenylalanyl-tRNA synthetase alpha subunit, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase [Saccharomyces [nrdb_11152004_Chlamydomonas]
  • MSF1 SGDID:S000006251, Chr XVI from 657526-658935, Verified ORF, "Mitochondrial phenylalanyl-tRNA synthetase alpha subunit, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the al [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • MSF1 SGDID:S000006251, Chr XVI from 657526-658935, Verified ORF, "Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of [yeast-200209-contam.fasta]
  • Mitochondrial phenylalanyl-tRNA synthetase alpha subunit, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase; Msf1p [Saccha [nr-271106-contam.fasta]
  • Phenylalanyl-tRNA synthetase, mitochondrial precursor (Phenylalanine--tRNA ligase) (PheRS) [nr-271106-contam.fasta]
  • MSF1 SGDID:S000006251, Chr XVI from 657526-658935, Verified ORF, "Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase" [yeast-bovrabprots.fasta]
  • MSF1 SGDID:S000006251, Chr XVI from 657526-658935, Verified ORF, "Mitochondrial phenylalanyl-tRNA synthetase alpha subunit, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase" [yeast-contam_custom.fasta]
  • [chemostatdb.fasta]
  • Phenylalanine--tRNA ligase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MSF1 PE=1 SV=3 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • MSF1 SGDID:S000006251, Chr XVI from 657529-658938, Genome Release 64-1-1, Verified ORF, "Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase" [yeast-030211-contam.fasta]
  • MSF1 SGDID:S000006251, Chr XVI from 657529-658938, Genome Release 64-2-1, Verified ORF, "Mitochondrial phenylalanyl-tRNA synthetase; active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase" [20141208_orf_trans.fasta]
  • YPR047W SGDID:S000006251, Chr XVI from 657529-658938, Genome Release 64-1-1, Verified ORF, "Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 469 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article][IMPLink to PubMed article]
    Biological Process: translation [IMPLink to PubMed article]
    Molecular Function: phenylalanine-tRNA ligase activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFLNRMMKTR TGLYRLYSTL KVPHVEINGI KYKTDPQTTN VTDSIIKLTD RSLHLKESHP  60
   61 VGILRDLIEK KLNSVDNTFK IFNNFKPVVT TMENFDSLGF PKDHPGRSKS DTYYINETHL 120
  121 LRTHTSAHEL ECFQKIRNDS DNIKSGFLIS ADVYRRDEID KTHYPVFHQM EGATIWKRTK 180
  181 ADVGVKEPMY IEKIREDIRQ VENLLNKENV KITVDDDTIP LKENNPKQEY MSDLEVDLCS 240
  241 QHLKRSIELI VSEVFNKKIS SMIKNKANNT PKELKVRWIN AYFPWTAPSW EIEVWWQGEW 300
  301 LELCGCGLIR QDVLLRAGYK PSETIGWAFG LGLDRIAMLL FEIPDIRLLW SRDERFSRQF 360
  361 SKGLITSFKP YSKHPGSFRD VAFWLPEDKP DIHQVHENDL MEIIRNIAGD LVESVKLVDS 420
  421 FTHPKTGRKS MCYRINYQSM DRNLTNAEVN TLQDMVCSKL VKEYSVELR

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) FRS1 FRS2 MSF1
    View Details Krogan NJ, et al. (2006) MSF1 TMA16 YNL024C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MSF1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..469] PSI-BLAST 49.0 Domains B1 and B5 of PheRS-beta, PheT; Domain B2 of PheRS-beta, PheT; Phenylalanyl-tRNA synthetase; Phenyl-tRNA synthetase (PheRS) beta subunit, PheT, central domain; B3/B4 domain of PheRS, PheT

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ligase activity, forming aminoacyl-tRNA and related compounds
    		•  7.89468709683036 bayes_pls_golite062009
  • ligase activity, forming carbon-oxygen bonds
    		•  7.89468709683036 bayes_pls_golite062009
  • aminoacyl-tRNA ligase activity
    		•  7.88410036819636 bayes_pls_golite062009
  • phenylalanine-tRNA ligase activity
    		•  7.1807508219467 bayes_pls_golite062009
  • ligase activity
    		•  6.92073480193262 bayes_pls_golite062009
  • serine-tRNA ligase activity
    		•  2.46505535069103 bayes_pls_golite062009
  • glycine-tRNA ligase activity
    		•  2.29229136935761 bayes_pls_golite062009
  • threonine-tRNA ligase activity
    		•  2.18642354927 bayes_pls_golite062009
  • catalytic activity
    		•  1.99372273395202 bayes_pls_golite062009
  • alanine-tRNA ligase activity
    		•  1.82594054955281 bayes_pls_golite062009
  • lysine-tRNA ligase activity
    		•  1.72324031407565 bayes_pls_golite062009
  • histidine-tRNA ligase activity
    		•  1.72215103383322 bayes_pls_golite062009
  • binding
    		•  0.966824335333342 bayes_pls_golite062009
  • asparagine-tRNA ligase activity
    		•  0.921492123574877 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.375542987753806 bayes_pls_golite062009
  • transcription activator activity
    		•  0.36727492354438 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.281662799812287 bayes_pls_golite062009
  • protein binding
    		•  0.0804954454681041 bayes_pls_golite062009
  • DNA binding
    		•  0.0309732052586011 bayes_pls_golite062009
  • RNA binding
    		•  0.0221706730298825 bayes_pls_golite062009
  • aspartate-tRNA ligase activity
    		•  0.00572514744734753 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle