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Protein Overview: CYC2

General Information:
Name(s) found: CYC2 / YOR037W [SGD]
Description(s) found:
Found 18 descriptions.
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  • Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p) [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 366 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    extrinsic to mitochondrial inner membrane [IDALink to PubMed article]
    Biological Process: cytochrome c-heme linkage [IGILink to PubMed articleLink to PubMed article]
    mitochondrial membrane organization [IMPLink to PubMed article]
    Molecular Function: oxidoreductase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLWKNYVLSS SRITRRLHKS PRKSSFSKNF FITGCLLTVG AVSSYLTYRY TSERENKHEL  60
   61 SPSYFVKYKI SHKRDIDSSH FLLEVTPLFK QKVNIWSLMT AENLWSVEIK QPEVMVVRNY 120
  121 TPLPLKFNPA SKEIEILKDG DNADGKLSFY IKKYENGEVA RWLHHLPKGH IIEIRGPFID 180
  181 YEFPHLPNEL KRSRDCLYMD NRNERGNNVR ENSQFIYQPY DIMMFTAGTG IVTALQLLLT 240
  241 ESPFRGTIKL FHTDKNIKQL GPLYPILLRL QASNRVQLKI FETDRQTKQD VLKSIQKSIT 300
  301 KPYPYKGLLP FSNVNNKNIM PVLALVCGPE SYISSISGRK YDLNQGPVGG LLSKEGWNSD 360
  361 NVYKLS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) CYC2 QCR7

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen EHD3 CYC2 1 Unpublished Fields Lab Data
    View Screen SPT21 CYC2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CYC2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..366] PSI-BLAST 51.0 cytochrome b5 reductase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • ferredoxin-NADP+ reductase activity
    		•  1.46342400843015 bayes_pls_golite062009
  • ferredoxin reductase activity
    		•  1.46342400843015 bayes_pls_golite062009
  • oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor
    		•  1.46342400843015 bayes_pls_golite062009
  • catalytic activity
    		•  1.45374095556065 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor
    		•  1.42015329094031 bayes_pls_golite062009
  • binding
    		•  1.1846867809187 bayes_pls_golite062009
  • transferase activity
    		•  1.15480450573972 bayes_pls_golite062009
  • cytochrome-b5 reductase activity
    		•  1.03329517603164 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  0.90349352746963 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  0.837374174980467 bayes_pls_golite062009
  • protein binding
    		•  0.452115023569428 bayes_pls_golite062009
  • adenyl nucleotide binding
    		•  0.380728782547069 bayes_pls_golite062009
  • riboflavin synthase activity
    		•  0.380537461428523 bayes_pls_golite062009
  • coenzyme binding
    		•  0.377407140593246 bayes_pls_golite062009
  • NADH dehydrogenase (ubiquinone) activity
    		•  0.316225866055591 bayes_pls_golite062009
  • oxidoreductase activity
    		•  0.27336340260908 bayes_pls_golite062009
  • purine nucleotide binding
    		•  0.178246305574472 bayes_pls_golite062009
  • nucleotide binding
    		•  0.172202492581267 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
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