Protein Overview: ITR2

General Information:
Name(s) found:	ITR2 / YOL103W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|37362691\|ref\|NP_014538.2\| Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively; Itr2p [Saccharomyces cerevisiae] [NCBI NR] gi\|115502408\|sp\|P30606.2\|ITR2_YEAST RecName: Full=Myo-inositol transporter 2 [NCBI NR] Myo-inositol transporter 2 OS=Saccharomyces cerevisiae GN=ITR2 PE=1 SV=2 [Swiss-Prot] ITR2 Inositol permease [mips] Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively [SGD] Chr XV from 124000-125829 [hmr_yeast5_DM3-1_pombe.fasta] ITR2 SGDID:S0005463, Chr XV from 124000-125829, Verified ORF [yeastflysequest.fasta] Itr2p [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas] ITR2 SGDID:S000005463, Chr XV from 124000-125829, Verified ORF, "Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] ITR2 SGDID:S000005463, Chr XV from 124001-125830, Verified ORF, "Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively" [yeast-contam.fasta] Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively; Itr2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Myo-inositol transporter 2 [nr-271106-contam.fasta] [chemostatdb.fasta] Myo-inositol transporter 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ITR2 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] ITR2 SGDID:S000005463, Chr XV from 124001-125830, Genome Release 64-1-1, Verified ORF, "Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively" [yeast-030211-contam.fasta] ITR2 SGDID:S000005463, Chr XV from 124001-125830, Genome Release 64-2-1, Verified ORF, "Myo-inositol transporter; member of the sugar transporter superfamily; expressed constitutively; ITR2 has a paralog, ITR1, that arose from the whole genome duplication" [20141208_orf_trans.fasta] YOL103W SGDID:S000005463, Chr XV from 124001-125830, Genome Release 64-1-1, Verified ORF, "Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	609 amino acids
Gene Ontology:
Cellular Component:	membrane [ISS] plasma membrane [IDA]
Biological Process:	myo-inositol transport [IMP]
Molecular Function:	myo-inositol transmembrane transporter activity [IMP][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKNSTAASSR WTKSRLSHFF PSYTNSSGMG AASTDQSSTQ GEELHHRKHC EEDNDGQKPK  60
   61 KSPVSTSTMQ IKSRQDEDED DGRIVIKPVN DEDDTSVIIT FNQSISPFII TLTFVASISG 120
  121 FMFGYDTGYI SSALISINRD LDNKVLTYGE KELITAATSL GALITSVGAG TAADVFGRRP 180
  181 CLMFSNLMFL IGAILQITAH KFWQMAAGRL IMGFGVGIGS LISPLFISEI APKMIRGRLT 240
  241 VINSLWLTGG QLIAYGCGAG LNHVKNGWRI LVGLSLIPTV LQFSFFCFLP DTPRYYVMKG 300
  301 DLKRAKMVLK RSYVNTEDEI IDQKVEELSS LNQSIPGKNP ITKFWNMVKE LHTVPSNFRA 360
  361 LIIGCGLQAI QQFTGWNSLM YFSGTIFETV GFKNSSAVSI IVSGTNFVFT LIAFFCIDKI 420
  421 GRRYILLIGL PGMTVALVIC AIAFHFLGIK FNGADAVVAS DGFSSWGIVI IVFIIVYAAF 480
  481 YALGIGTVPW QQSELFPQNV RGVGTSYATA TNWAGSLVIA STFLTMLQNI TPTGTFSFFA 540
  541 GVACLSTIFC YFCYPELSGL ELEEVQTILK DGFNIKASKA LAKKRKQQVA EGAAHHKLKF 600
  601 EPTQEIVES

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Ho Y, et al. (2002)		HAL5 ITR2
View Details	Qiu et al. (2008)		FPS1 ITR1 ITR2

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CTF13	ITR2	1	Unpublished Fields Lab Data
View Screen	CTR86	ITR2	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	ITR2	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..103]	deduced	N/A	No confident structure predictions are available.
2	View Details	[104..609]	PSI-BLAST	36.0	Crystal Structure of the Glycerol-3-Phosphate Transporter from E.Coli

Functions predicted (by domain):

Gene Ontology predictions

No functions predicted.

Term	Confidence	Notes
glycerol transmembrane transporter activity	7.11654923455995	bayes_pls_golite062009
alcohol transmembrane transporter activity	6.7545566917184	bayes_pls_golite062009
polyol transmembrane transporter activity	6.7545566917184	bayes_pls_golite062009
glycerol-3-phosphate transmembrane transporter activity	5.74077413704789	bayes_pls_golite062009
transporter activity	4.09176719149278	bayes_pls_golite062009
substrate-specific transporter activity	3.59744164024479	bayes_pls_golite062009
transmembrane transporter activity	3.5865018981083	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	3.54194478414824	bayes_pls_golite062009
hexose phosphate transmembrane transporter activity	3.3746965264994	bayes_pls_golite062009
glucose-6-phosphate transmembrane transporter activity	3.3746965264994	bayes_pls_golite062009
sugar:hydrogen symporter activity	2.99050613058546	bayes_pls_golite062009
cation:sugar symporter activity	2.99050613058546	bayes_pls_golite062009
monosaccharide transmembrane transporter activity	2.63293544825311	bayes_pls_golite062009
carbohydrate transmembrane transporter activity	2.62141276633776	bayes_pls_golite062009
sugar transmembrane transporter activity	2.47557586092261	bayes_pls_golite062009
ion transmembrane transporter activity	2.21266150105753	bayes_pls_golite062009
solute:hydrogen symporter activity	2.10485633822652	bayes_pls_golite062009
binding	1.89539096965643	bayes_pls_golite062009
cation transmembrane transporter activity	1.79369588808394	bayes_pls_golite062009
active transmembrane transporter activity	1.59419818573076	bayes_pls_golite062009
secondary active transmembrane transporter activity	1.22264637452409	bayes_pls_golite062009
symporter activity	0.74591237387473	bayes_pls_golite062009
solute:cation symporter activity	0.74591237387473	bayes_pls_golite062009
sugar binding	0.285073104957756	bayes_pls_golite062009

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2