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Protein Overview: IZH2

General Information:
Name(s) found: IZH2 / YOL002C [SGD]
Description(s) found:
Found 24 descriptions.
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  • Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 317 amino acids

    Gene Ontology:
    Cellular Component: membrane [ISSLink to PubMed article]
    integral to membrane [ISSLink to PubMed article]
    plasma membrane [IDALink to PubMed article]
    Biological Process: response to zinc ion [ISSLink to PubMed article]
    lipid metabolic process [TASLink to PubMed article]
    cellular zinc ion homeostasis [IMPLink to PubMed article][ISSLink to PubMed article]
    response to toxin [IMPLink to PubMed article]
    Molecular Function: protein binding [IPILink to PubMed article]
    metal ion binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTLLERTKS VQELKKRAAG KTSANPAEVA KAKKVLRRLY SWDEIPEWQR DNDFILHGYV  60
   61 KETSSFIETF KSLFYLHNES VNIYSHLIPA LGFFTVLLLD KSTIKVFATT TWLDHMVIDL 120
  121 FYSGAFACLI LSSSFHCLKS HSLRIATLGN KLDYLGICIL IVTSMVSILY YGYFEKFSLF 180
  181 CLFALITVSF GIACSIVSLK DKFRKREWRP YRAGLFVCFG LSSIIPIFSG LYCYSFSEIW 240
  241 TQIQLFWVLL GGVLYIIGAV LYGMRFPEKI CPGKFDIWGH SHQLFHFLVV IAALCHLRGL 300
  301 LNSYELVHIK MENGIVS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) IZH2 IZH4

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..120] deduced N/A No confident structure predictions are available.
    2 View Details [121..317] MSA 6.127987 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle