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Protein Overview: IZH4

General Information:
Name(s) found: IZH4 / YOL101C [SGD]
Description(s) found:
Found 33 descriptions.
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  • Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 312 amino acids

    Gene Ontology:
    Cellular Component: membrane [ISSLink to PubMed article][TASLink to PubMed article]
    integral to membrane [ISSLink to PubMed article]
    Biological Process: lipid metabolic process [TASLink to PubMed article]
    cellular zinc ion homeostasis [IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: metal ion binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVSLTTIEQS PVKCETTTEK ESNDTRGTDS NENAETKETK KGFPFHDLAK LQKQYKNKSS  60
   61 RNESLVALIY LLGSMLSFCL LIFFTDFYLI PLFPTTTTMT DYIVFNFYLL NVFVFCMVHF 120
  121 IYHFVKNISL QQHLEHWQKF SYLSNINLLI SSQITILYYL FYDYVFFFKI FTLLMNFIGL 180
  181 VAYFFILTDK LISSKRFNKT VFFISVSVVC CSLPLLTAII TFDGLENLKE RIKVNAITWE 240
  241 LVALVAASII YVTRFPESLF RRNKKEEGWN HSEYLFHLLI SGTAFYHFFI LIQSYILMHS 300
  301 SLNQPELINF KS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) IZH1 IZH2 IZH4

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data IZH4 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..312] Pfam 109.958607 Haemolysin-III related No confident structure predictions are available.
    2 View Details [157..312] MSA 15.306997 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle