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Protein Overview: MET13

General Information:
Name(s) found: MET13 / YGL125W [SGD]
Description(s) found:
Found 18 descriptions.
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  • Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 600 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    mitochondrial large ribosomal subunit [IDALink to PubMed article]
    Biological Process: sulfur amino acid biosynthetic process [TASLink to PubMed article]
    translation [IDALink to PubMed article]
    methionine metabolic process [IMPLink to PubMed article][TASLink to PubMed article]
    Molecular Function: structural constituent of ribosome [IDALink to PubMed article]
    methylenetetrahydrofolate reductase (NADPH) activity [IDALink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKITEKLEQH RQTSGKPTYS FEYFVPKTTQ GVQNLYDRMD RMYEASLPQF IDITWNAGGG  60
   61 RLSHLSTDLV ATAQSVLGLE TCMHLTCTNM PISMIDDALE NAYHSGCQNI LALRGDPPRD 120
  121 AENWTPVEGG FQYAKDLIKY IKSKYGDHFA IGVAGYPECH PELPNKDVKL DLEYLKQKID 180
  181 AGGDFIITQM FYDVDNFINW CSQVRAAGMD VPIIPGIMPI TTYAAFLRRA QWGQISIPQH 240
  241 FSSRLDPIKD DDELVRDIGT NLIVEMCQKL LDSGYVSHLH IYTMNLEKAP LMILERLNIL 300
  301 PTESEFNAHP LAVLPWRKSL NPKRKNEEVR PIFWKRRPYS YVARTSQWAV DEFPNGRFGD 360
  361 SSSPAFGDLD LCGSDLIRQS ANKCLELWST PTSINDVAFL VINYLNGNLK CLPWSDIPIN 420
  421 DEINPIKAHL IELNQHSIIT INSQPQVNGI RSNDKIHGWG PKDGYVYQKQ YLEFMLPKTK 480
  481 LPKLIDTLKN NEFLTYFAID SQGDLLSNHP DNSKSNAVTW GIFPGREILQ PTIVEKISFL 540
  541 AWKEEFYHIL NEWKLNMNKY DKPHSAQFIQ SLIDDYCLVN IVDNDYISPD DQIHSILLSL 600
  601

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) MET12 MET13
    View Details Gavin AC, et al. (2006) MET12 MET13

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MET13 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..309] PSI-BLAST 94.39794 5,10-Methylenetetrahydrofolate Reductase from Thermus thermophilus HB8
    2 View Details [310..453] deduced N/A Confident ab initio structure predictions are available.
    3 View Details [454..508] deduced N/A No confident structure predictions are available.
    4 View Details [509..600] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • methylenetetrahydrofolate reductase (NADPH) activity
    		•  3.97406471031265 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors
    		•  3.43788898294589 bayes_pls_golite062009
  • oxidoreductase activity
    		•  3.26500423104107 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
    		•  2.35093189018748 bayes_pls_golite062009
  • catalytic activity
    		•  2.15527229494088 bayes_pls_golite062009
  • 1-pyrroline-5-carboxylate dehydrogenase activity
    		•  2.11575302268542 bayes_pls_golite062009
  • binding
    		•  1.55766253746824 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.413628997019645 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.385543917258092 bayes_pls_golite062009
  • protein binding
    		•  0.229798056306674 bayes_pls_golite062009
  • DNA binding
    		•  0.214617895050106 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle