Protein Overview: MCM16

General Information:
Name(s) found:	MCM16 / YPR046W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|805029\|emb\|CAA89166.1\| unknown [Saccharomyces cerevisiae] [NCBI NR] gi\|74655040\|sp\|Q12262.1\|MCM16_YEAST RecName: Full=Central kinetochore subunit MCM16; AltName: Full=Minichromosome maintenance protein 16 [NCBI NR] gi\|6325303\|ref\|NP_015371.1\| Protein involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; Mcm16p [Saccharomyces cerevisiae] [NCBI NR] gi\|1314117\|emb\|CAA94993.1\| unknown [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S54070 hypothetical protein YPR046w - yeast (Saccharomyces cerevisiae) [NCBI NR] Central kinetochore subunit MCM16 OS=Saccharomyces cerevisiae GN=MCM16 PE=1 SV=1 [Swiss-Prot] MCM16 Outer kinetochore protein [mips] Protein involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA [SGD] >Q12262 (Q12262) MCM16 protein [4932.FASTACCERV.txt] Chr XVI from 656794-657339 [hmr_yeast5_DM3-1_pombe.fasta] MCM16, Chr XVI from 656794-657339 [yeast_orfs2] MCM16 SGDID:S0006250, Chr XVI from 656794-657339, Verified ORF [yeastflysequest.fasta] MCM16 SGDID:S0006250, Chr XVI from 656796-657341, Verified ORF [10112005cervSGD.fasta] Mcm16p [Saccharomyces cerevisiae]gi\|805029\|emb\|CAA89166.1\| unknown [Saccharomyces cerevisiae]gi\|1314117\|emb\|CAA94993.1\| unknown [Saccharomyces cerevisiae]gi\|1084779\|pir\|\|S54070 hypothetical protein YPR046w - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas] (Q12262) Hypothetical protein YPR042W [cerv4932.FASTAC] MCM16 SGDID:S000006250, Chr XVI from 656796-657341, Verified ORF, "Protein involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Protein involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; Mcm16p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Central kinetochore subunit MCM16 (Minichromosome maintenance protein 16) [nr-271106-contam.fasta] [chemostatdb.fasta] Central kinetochore subunit MCM16 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MCM16 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] MCM16 SGDID:S000006250, Chr XVI from 656799-657344, Genome Release 64-1-1, Verified ORF, "Protein involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA" [yeast-030211-contam.fasta] MCM16 SGDID:S000006250, Chr XVI from 656799-657344, Genome Release 64-2-1, Verified ORF, "Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3" [20141208_orf_trans.fasta] TR5345\|c0_g1_i1\|g.3614 ORF TR5345\|c0_g1_i1\|g.3614 TR5345\|c0_g1_i1\|m.3614 type:complete len:182 (+) TR5345\|c0_g1_i1:103-648(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta] YPR046W SGDID:S000006250, Chr XVI from 656799-657344, Genome Release 64-1-1, Verified ORF, "Protein involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta] ID=asmbl_3250\|g.2183 ORF ID=asmbl_3250\|g.2183 ID=asmbl_3250\|m.2183 type:complete len:182 (+) ID=asmbl_3250:103-648(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
Organism:	Saccharomyces cerevisiae
Length:	181 amino acids
Gene Ontology:
Cellular Component:	condensed nuclear chromosome kinetochore [IDA]
Biological Process:	chromosome segregation [IPI]
Molecular Function:	protein binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTNSSEKQWE RIQQLEKEHV EVYRELLITL DRLYLIRKHN HAVILSHTQQ RLLEIRHQLQ  60
   61 INLEKTALLI RLLEKPDNTN VLFTKLQNLL EESNSLDYEL LQSLGAQSSL HKQLIESRAE 120
  121 RDELMSKLIE LSSKFPKPTI PPDDSDTAGK QVEVEKENET IQELMIALQI HSGYTNISYT 180
  181 I

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	(MIPS) Mewes HW, et al. (2004)		CTF3 MCM16 MCM22
View Details	Krogan NJ, et al. (2006)		AME1 ARG5,6 CHL4 CTF19 CTF3 IML3 MCM16 MCM21 MCM22 NKP1 NKP2 OKP1 PRP18 SET4 YNR062C
View Details	Qiu et al. (2008)		MCM16 MCM21 MCM22

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	CHL4	No Comments	Cheeseman IM, et al. (2002)
View Run	MCM16	No Comments	Cheeseman IM, et al. (2002)
View Run	NSL1	No Comments	Hazbun TR, et al. (2003)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

	PROTEIN(S)	PUBLICATION
View Data	MCM16	Huh WK, et al. (2003)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..181]	Pcons	1.88	Granulocyte-colony stimulating factor (G-CSF)

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: MCM16

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: