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Protein Overview: SUT2

General Information:
Name(s) found: SUT2 / YPR009W [SGD]
Description(s) found:
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  • gi|939743|gb|AAA97588.1| Lpz9p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|887586|emb|CAA90153.1| unknown [Saccharomyces cerevisiae] [NCBI NR]
  • gi|74583832|sp|Q12286.1|SUT2_YEAST RecName: Full=Sterol uptake protein 2 [NCBI NR]
  • gi|6325266|ref|NP_015334.1| Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p; Sut2p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S57542 hypothetical protein YPR009w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1314084|emb|CAA95049.1| unknown [Saccharomyces cerevisiae] [NCBI NR]
  • Sterol uptake protein 2 OS=Saccharomyces cerevisiae GN=SUT2 PE=2 SV=1 [Swiss-Prot]
  • SUT2 Involved in sterol uptake [mips]
  • Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p [SGD]
  • >Q12286 (Q12286) Hypothetical protein YPR009W [4932.FASTACCERV.txt]
  • Chr XVI from 576547-577353 [hmr_yeast5_DM3-1_pombe.fasta]
  • YPR009W, Chr XVI from 576547-577353 [yeast_orfs2]
  • SUT2 SGDID:S0006213, Chr XVI from 576547-577353, Verified ORF [yeastflysequest.fasta]
  • SUT2 SGDID:S0006213, Chr XVI from 576549-577355, Verified ORF [10112005cervSGD.fasta]
  • Involved in sterol uptake; homologous to SUT1 [Saccharomyces cerevisiae]gi|887586|emb|CAA90153.1| unknown [Saccharomyces cerevisiae]gi|1314084|emb|CAA95049.1| unknown [Saccharomyces cerevisiae]gi|1362405|pir||S57542 hypothetical protein YPR009w - yeast [nrdb_11152004_Chlamydomonas]
  • (Q12286) Hypothetical protein YPR009W (Lpz9p) [cerv4932.FASTAC]
  • SUT2 SGDID:S000006213, Chr XVI from 576549-577355, Verified ORF, "Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p; Sut2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Lpz9p [nr-271106-contam.fasta]
  • Sterol uptake protein 2 [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Sterol uptake protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SUT2 PE=2 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • SUT2 SGDID:S000006213, Chr XVI from 576552-577358, Genome Release 64-1-1, Verified ORF, "Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p" [yeast-030211-contam.fasta]
  • Sterol uptake protein 2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SUT2 PE=3 SV=1 [YEAST.fasta.20131015]
  • SUT2 SGDID:S000006213, Chr XVI from 576552-577358, Genome Release 64-2-1, Verified ORF, "Putative transcription factor of the Zn2Cys6 family; regulates sterol uptake under anaerobic conditions along with SUT1; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; positively regulates mating along with SUT1 by repressing the expression of genes (PRR2, NCE102 and RHO5) which function as mating inhibitors; SUT2 has a paralog, SUT1, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YPR009W SGDID:S000006213, Chr XVI from 576552-577358, Genome Release 64-1-1, Verified ORF, "Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 268 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    Biological Process: sterol transport [IMPLink to PubMed article]
    regulation of transcription from RNA polymerase II promoter [IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: specific RNA polymerase II transcription factor activity [IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKPNNRTCDV ITNKDESLPA LLLPALNSYT CDDSLLKGQI SSNGRYQPFG FSDCSLLPKR  60
   61 LNIQAGQGSM PVSSIQCADH SYSNWQKESE KTKLPKLGCP TEYTEYYKTV SSGETTDSAV 120
  121 VSSIATNRLK RKRQRDGPSC DSCRIKKIKC NATIIIFLQD RNLISSISSN LHYTLSQDDI 180
  181 NQFRMKFFRK LPDVMGTYEV IKHLDKIVLF KACTSCSRRN QKNGKCLFSR GFTKSDMNVF 240
  241 PKINSKLKDK SIFEMTVDDY VAAGFQTL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..268] deduced N/A No confident structure predictions are available.
    2 View Details [117..268] FFAS03 2.8 PPR1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  4.34861813464065 bayes_pls_golite062009
  • DNA binding
    		•  4.03985756894684 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.97978190843512 bayes_pls_golite062009
  • transcription factor activity
    		•  2.87348461329489 bayes_pls_golite062009
  • binding
    		•  2.82809978070212 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.70904317608141 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  2.08956709478484 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  1.67344049333457 bayes_pls_golite062009
  • transcription activator activity
    		•  0.822069987038721 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle