YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: CIT3

General Information:
Name(s) found: CIT3 / YPR001W [SGD]
Description(s) found:
Found 32 descriptions.
SHOW ALL
  • Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 486 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [NASLink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    Biological Process: citrate metabolic process [TASLink to PubMed article]
    propionate metabolic process [IEPLink to PubMed article]
    tricarboxylic acid cycle [TASLink to PubMed article]
    Molecular Function: citrate (Si)-synthase activity [TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVQRLLPGAH ICRRSFNSSA IIKSSALTLK EALENVIPKK RDAVKKLKAC YGSTFVGPIT  60
   61 ISSVLGGMRG NQSMFWQGTS LDPEHGIKFQ GLTIEECQNR LPNTGIDGDN FLPESMLWLL 120
  121 MTGGVPTFQQ AASFRKELAI RGRKLPHYTE KVLSSLPKDM HPMTQLAIGL ASMNKGSLFA 180
  181 TNYQKGLIGK MEFWKDTLED SLNLIASLPL LTGRIYSNIT NEGHPLGQYS EEVDWCTNIC 240
  241 SLLGMTNGTN SSNTCNLTSQ QSLDFINLMR LYTGIHVDHE GGNVSAHTTH LVGSALSDPY 300
  301 LSYSSGIMGL AGPLHGLAAQ EVVRFLIEMN SNISSIAREQ EIKDYLWKIL NSNRVIPGYG 360
  361 HAVLRKPDPR FTAMLEFAQK RPIEFENDKN VLLMQKLAEI APKVLLEHGK SKNPFPNVDS 420
  421 ASGILFYHYG IRELLFFTVI FGCSRAMGPL TQLVWDRILG LPIERPKSLN LEGLEALTKA 480
  481 SNVNKL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) CIT1 CIT2 CIT3 FUM1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CIT3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..319]
    [427..486]    		 PSI-BLAST 1337.0 Citrate synthase
    2 View Details [320..426] PSI-BLAST 1337.0 Citrate synthase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • citrate (Si)-synthase activity
    		•  7.90380661459876 bayes_pls_golite062009
  • transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
    		•  7.35970609422108 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  4.98392594633005 bayes_pls_golite062009
  • catalytic activity
    		•  2.51855037019879 bayes_pls_golite062009
  • transferase activity
    		•  2.22659761972612 bayes_pls_golite062009
  • binding
    		•  1.15467737113069 bayes_pls_golite062009
  • protein binding
    		•  0.210158634792359 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle