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View Structure Prediction Details

Protein: CIT3
Organism: Saccharomyces cerevisiae
Length: 486 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CIT3.

Description E-value Query
Range		 Subject
Range
CISY_PIG - Citrate synthase, mitochondrial OS=Sus scrofa GN=CS PE=1 SV=2
gi|68227 - pir||YKPG citrate (si)-synthase (EC 4.1.3.7) precursor - pig
 0.0 [4..481] [9..464]
CISY_MOUSE - Citrate synthase, mitochondrial OS=Mus musculus GN=Cs PE=1 SV=1
 0.0 [3..481] [8..464]
CS - citrate synthase
 0.0 [4..482] [9..465]
CISY_XENLA - Citrate synthase, mitochondrial OS=Xenopus laevis GN=cs PE=2 SV=1
 0.0 [4..482] [12..467]
CISY_RAT - Citrate synthase, mitochondrial OS=Rattus norvegicus GN=Cs PE=1 SV=1
 0.0 [4..482] [9..465]
CISY_DANRE - Citrate synthase, mitochondrial OS=Danio rerio GN=cs PE=2 SV=1
 0.0 [2..478] [6..463]

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Predicted Domain #1
Region A:
Residues: [1-319] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVQRLLPGAH ICRRSFNSSA IIKSSALTLK EALENVIPKK RDAVKKLKAC YGSTFVGPIT  60
   61 ISSVLGGMRG NQSMFWQGTS LDPEHGIKFQ GLTIEECQNR LPNTGIDGDN FLPESMLWLL 120
  121 MTGGVPTFQQ AASFRKELAI RGRKLPHYTE KVLSSLPKDM HPMTQLAIGL ASMNKGSLFA 180
  181 TNYQKGLIGK MEFWKDTLED SLNLIASLPL LTGRIYSNIT NEGHPLGQYS EEVDWCTNIC 240
  241 SLLGMTNGTN SSNTCNLTSQ QSLDFINLMR LYTGIHVDHE GGNVSAHTTH LVGSALSDPY 300
  301 LSYSSGIMGL AGPLHGLAA

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [427-486] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YHYGIRELLF FTVIFGCSRA MGPLTQLVWD RILGLPIERP KSLNLEGLEA LTKASNVNKL  60
   61

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1337.0
Match: 1cts__
Description: Citrate synthase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
citrate (Si)-synthase activity 7.90380661459876 bayes_pls_golite062009
transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer 7.35970609422108 bayes_pls_golite062009
transferase activity, transferring acyl groups 4.98392594633005 bayes_pls_golite062009
catalytic activity 2.51855037019879 bayes_pls_golite062009
transferase activity 2.22659761972612 bayes_pls_golite062009
binding 1.15467737113069 bayes_pls_golite062009
protein binding 0.210158634792359 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [320-426] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QEVVRFLIEM NSNISSIARE QEIKDYLWKI LNSNRVIPGY GHAVLRKPDP RFTAMLEFAQ  60
   61 KRPIEFENDK NVLLMQKLAE IAPKVLLEHG KSKNPFPNVD SASGILF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 1337.0
Match: 1cts__
Description: Citrate synthase
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle