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Protein Overview: PCL8

General Information:
Name(s) found: PCL8 / YPL219W [SGD]
Description(s) found:
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  • gi|74583779|sp|Q08966.1|PCL8_YEAST RecName: Full=PHO85 cyclin-8 [NCBI NR]
  • gi|6325037|ref|NP_015105.1| Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation; Pcl8p [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S65238 probable membrane protein YPL219w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1370454|emb|CAA97934.1| PCL8 [Saccharomyces cerevisiae] [NCBI NR]
  • PHO85 cyclin-8 OS=Saccharomyces cerevisiae GN=PCL8 PE=1 SV=1 [Swiss-Prot]
  • PCL8 Cyclin like protein interacting with Pho85p [mips]
  • Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation [SGD]
  • >Q08966 (Q08966) Chromosome XVI reading frame ORF YPL219W [4932.FASTACCERV.txt]
  • Chr XVI from 136749-138227 [hmr_yeast5_DM3-1_pombe.fasta]
  • PCL8, Chr XVI from 136749-138227 [yeast_orfs2]
  • PCL8 SGDID:S0006140, Chr XVI from 136749-138227, Verified ORF [yeastflysequest.fasta]
  • Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation [Saccharomyces cerevisiae]gi|1370454|emb|CAA97934.1| PCL8 [Saccharomyces cerevisiae]gi|2133003|p [nrdb_11152004_Chlamydomonas]
  • (Q08966) PCL8 protein [cerv4932.FASTAC]
  • PCL8 SGDID:S000006140, Chr XVI from 136749-138227, Verified ORF, "Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation; Pcl8p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • PCL8 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • PHO85 cyclin-8 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PCL8 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • PCL8 SGDID:S000006140, Chr XVI from 136750-138228, Genome Release 64-1-1, Verified ORF, "Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation" [yeast-030211-contam.fasta]
  • PCL8 SGDID:S000006140, Chr XVI from 136750-138228, Genome Release 64-2-1, Verified ORF, "Cyclin; interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation; PCL8 has a paralog, PCL10, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YPL219W SGDID:S000006140, Chr XVI from 136750-138228, Genome Release 64-1-1, Verified ORF, "Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 492 amino acids

    Gene Ontology:
    Cellular Component: cyclin-dependent protein kinase holoenzyme complex [TASLink to PubMed article]
    Biological Process: regulation of glycogen biosynthetic process [IGILink to PubMed article][IMPLink to PubMed article]
    regulation of glycogen catabolic process [IGILink to PubMed article]
    Molecular Function: cyclin-dependent protein kinase regulator activity [ISSLink to PubMed article][TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MANDQDPNKS LINDALTRSM SEFYDDDDDN DSDMCRANDE GEDVFDLPLK VGVSQSRNFS  60
   61 EVNDVLDPLS SLHGPSKKVR FEQQKQQQQH QQLHNDFNTD FNLKSPSSKK MGVEQLIQSA 120
  121 NEINDYLANN IDKVNSFNSE LLSGSGKLPG RVKSDTATQG TGRLDSMSNF ALSDTELDND 180
  181 DDNYLLDPLA NASSTTPTVE HHGYSLLDKA LSTSDKEKIY TNKVNSNSQI DTDNHSHESG 240
  241 NTTNNETDEN ESSEILDYTK FDSFPYPPSS APNGEPPDLK VLSIECEQEN EKELRRISLL 300
  301 LDHYESIPKI PELSDDEALS KFRENIELIL QLSKKINDNA NTLAISSEDP QKFVNFVMKN 360
  361 PPSLSFRDFI DRIQNKCMFG AVVYLGATYL LQLVFLTRDE MDGPIKLKAK LQEDQAHRII 420
  421 ISTIRIATKL LEDFVHSQNY ICKVFGISKR LLTKLEISFM ASVNFDGLMI TCEKLEKTLH 480
  481 ILDDTRQALG NT

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) PCL8 PHO85
    View Details (MIPS) Mewes HW, et al. (2004) PCL1 PCL10 PCL2 PCL8 PHO80 PHO85
    View Details Krogan NJ, et al. (2006) MMR1 PCL6 PCL8 PHO85
    View Details Qiu et al. (2008) CLG1 PCL10 PCL2 PCL6 PCL7 PCL8 PCL9 PHO80

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen PHO85 PCL8 2 Uetz P, et al. (2000)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PCL8 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..290] deduced N/A No confident structure predictions are available.
    2 View Details [291..492] MSA 41.076995 View MSA. No confident structure predictions are available.
    3 View Details [309..492] FFAS03 1.39 Viral cyclin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • cyclin-dependent protein kinase regulator activity
    		•  5.12463430024071 bayes_pls_golite062009
  • cyclin-dependent protein kinase activity
    		•  1.93343502830716 bayes_pls_golite062009
  • binding
    		•  1.73927974260891 bayes_pls_golite062009
  • protein binding
    		•  1.37207701115974 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.31222872955439 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.802637318318368 bayes_pls_golite062009
  • kinase regulator activity
    		•  0.753288291901404 bayes_pls_golite062009
  • protein kinase regulator activity
    		•  0.713321295552366 bayes_pls_golite062009
  • DNA binding
    		•  0.660292655137288 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.461517963237846 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.290993164406505 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  0.181080585275576 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.87

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle