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Protein Overview: DDC1

General Information:
Name(s) found: DDC1 / YPL194W [SGD]
Description(s) found:
Found 23 descriptions.
SHOW ALL
  • DNA damage checkpoint protein, part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 612 amino acids

    Gene Ontology:
    Cellular Component: condensed nuclear chromosome [IDALink to PubMed article]
    Biological Process: cell cycle checkpoint [IMPLink to PubMed article]
    recombinational repair [IDALink to PubMed article][IGILink to PubMed article]
    meiosis [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFKATITES GKQNIWFRAI YVLSTIQDDI KITVTTNELI AWSMNETDTT LCQVRFQKSF  60
   61 FEEYEFKPHE IVFGENGVQV IEDTYGNSHK LYSFRVNGRH LTTISRKPDG DGIKSFTIAV 120
  121 NNTSTCPESL ANRLIVVIEM DSLIVKEYCP QFQPIKYDPI IINLKYKRRF LDVFGTAASD 180
  181 RNPQEPLDPK LLDVFTNTER ELTSALFNEE VESDIRKRNQ LTAADEINYI CCNSTLLKNF 240
  241 LDNCNVNVTD EVKLEINVHR LSITAFTKAV YGKNNDLLRN ALSMSNTIST LDLEHYCLFT 300
  301 TIEDEKQDKR SHSKRREHMK SIIFKLKDFK NFITIGPSWK TTQDGNDNIS LWFCHPGDPI 360
  361 LMQMQKPGVK LELVEVTDSN INDDILEGKF IKTAISGSKE EAGLKDNKES CESPLKSKTA 420
  421 LKRENLPHSV AGTRNSPLKV SYLTPDNGST VAKTYRNNTA RKLFVEEQSQ STNYEQDKRF 480
  481 RQASSVHMNM NREQSFDIGT THEVACPRNE SNSLKRSIAD ICNETEDPTQ QSTFAKRADT 540
  541 TVTWGKALPA ADDEVSCSNI DRKGMLKKEK LKHMQGLLNS QNDTSNHKKQ DNKEMEDGLG 600
  601 LTQVEKPRGI FD

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) DDC1 MEC3
    View Details Ho Y, et al. (2002) DDC1 MEC3 RFC4 SUV3

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RAD17 DDC1 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data DDC1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..612] deduced N/A No confident structure predictions are available.
    2 View Details [380..612] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • DNA-directed DNA polymerase activity
    		•  3.42445034513733 bayes_pls_golite062009
  • DNA polymerase activity
    		•  3.38846098516892 bayes_pls_golite062009
  • DNA binding
    		•  2.04318251261279 bayes_pls_golite062009
  • nucleic acid binding
    		•  2.01144876655621 bayes_pls_golite062009
  • binding
    		•  1.89545142352738 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  1.06294354174876 bayes_pls_golite062009
  • structure-specific DNA binding
    		•  0.747485459405256 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.650750512308684 bayes_pls_golite062009
  • DNA polymerase processivity factor activity
    		•  0.614549267405772 bayes_pls_golite062009
  • catalytic activity
    		•  0.474398499157949 bayes_pls_golite062009
  • protein binding
    		•  0.455721709236539 bayes_pls_golite062009
  • double-stranded DNA binding
    		•  0.397447452409526 bayes_pls_golite062009
  • mismatched DNA binding
    		•  0.360278840045828 bayes_pls_golite062009
  • DNA insertion or deletion binding
    		•  0.130265364927567 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle