YRC Public Data Repository - Protein Structure Prediction

Protein:	DDC1
Organism:	Saccharomyces cerevisiae
Length:	612 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DDC1.

Description	E-value	Query Range	Subject Range
DDC1_YEAST - DNA damage checkpoint protein 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=DDC1 PE=... gi\|151942605 - gi\|151942605\|gb\|EDN60951.1\| DNA damage checkpoint [Saccharomyces cerevisiae YJM789] DDC1 - DNA damage checkpoint protein, part of a PCNA-like complex required for DNA damage response, require...	0.0	[1..612]	[1..612]

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Predicted Domain #1

Region A:
Residues: [1-612]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFKATITES GKQNIWFRAI YVLSTIQDDI KITVTTNELI AWSMNETDTT LCQVRFQKSF  60
   61 FEEYEFKPHE IVFGENGVQV IEDTYGNSHK LYSFRVNGRH LTTISRKPDG DGIKSFTIAV 120
  121 NNTSTCPESL ANRLIVVIEM DSLIVKEYCP QFQPIKYDPI IINLKYKRRF LDVFGTAASD 180
  181 RNPQEPLDPK LLDVFTNTER ELTSALFNEE VESDIRKRNQ LTAADEINYI CCNSTLLKNF 240
  241 LDNCNVNVTD EVKLEINVHR LSITAFTKAV YGKNNDLLRN ALSMSNTIST LDLEHYCLFT 300
  301 TIEDEKQDKR SHSKRREHMK SIIFKLKDFK NFITIGPSWK TTQDGNDNIS LWFCHPGDPI 360
  361 LMQMQKPGVK LELVEVTDSN INDDILEGKF IKTAISGSKE EAGLKDNKES CESPLKSKTA 420
  421 LKRENLPHSV AGTRNSPLKV SYLTPDNGST VAKTYRNNTA RKLFVEEQSQ STNYEQDKRF 480
  481 RQASSVHMNM NREQSFDIGT THEVACPRNE SNSLKRSIAD ICNETEDPTQ QSTFAKRADT 540
  541 TVTWGKALPA ADDEVSCSNI DRKGMLKKEK LKHMQGLLNS QNDTSNHKKQ DNKEMEDGLG 600
  601 LTQVEKPRGI FD

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
DNA-directed DNA polymerase activity	3.42445034513733	bayes_pls_golite062009
DNA polymerase activity	3.38846098516892	bayes_pls_golite062009
DNA binding	2.04318251261279	bayes_pls_golite062009
nucleic acid binding	2.01144876655621	bayes_pls_golite062009
binding	1.89545142352738	bayes_pls_golite062009
nucleotidyltransferase activity	1.06294354174876	bayes_pls_golite062009
structure-specific DNA binding	0.747485459405256	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.650750512308684	bayes_pls_golite062009
DNA polymerase processivity factor activity	0.614549267405772	bayes_pls_golite062009
catalytic activity	0.474398499157949	bayes_pls_golite062009
protein binding	0.455721709236539	bayes_pls_golite062009
double-stranded DNA binding	0.397447452409526	bayes_pls_golite062009
mismatched DNA binding	0.360278840045828	bayes_pls_golite062009
DNA insertion or deletion binding	0.130265364927567	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [380-612]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NINDDILEGK FIKTAISGSK EEAGLKDNKE SCESPLKSKT ALKRENLPHS VAGTRNSPLK  60
   61 VSYLTPDNGS TVAKTYRNNT ARKLFVEEQS QSTNYEQDKR FRQASSVHMN MNREQSFDIG 120
  121 TTHEVACPRN ESNSLKRSIA DICNETEDPT QQSTFAKRAD TTVTWGKALP AADDEVSCSN 180
  181 IDRKGMLKKE KLKHMQGLLN SQNDTSNHKK QDNKEMEDGL GLTQVEKPRG IFD