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Protein Overview: CUP9

General Information:
Name(s) found: CUP9 / YPL177C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 306 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISSLink to PubMed article]
    Biological Process: cellular copper ion homeostasis [IMPLink to PubMed article]
    transcription initiation from RNA polymerase II promoter [ISSLink to PubMed article]
    Molecular Function: specific RNA polymerase II transcription factor activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNYNCEIQNR NSKNVDNQVS LPPIQVLFNS IEKRSMPELA FSNIEYSHGN LRSSTEEQNY  60
   61 PAPVLLPQHH SIAYPAINSG GTSTTATPTA STVETSKTSS SAMDTQSQYG SSKKSKSASD 120
  121 DAKPCYKSAP IYEIINKEKD AGAQYNRPFS DFVESKSRRK QNSGRRSNLP KETVQILNTW 180
  181 LLNHLNNPYP TQQEKRELLI KTGLTKIQLS NWFINVRRRK IFSDYYTLVN SIPNDNANNT 240
  241 PVERVQNVSA YHNTLSATNN TMYDATSTCS TDYELSKRFA HAPVTRRKKL IDRLEELKKL 300
  301 SNPDMN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) CUP9 NDC1 YPT11

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CUP9 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..127] MSA 6.263995 View MSA. No confident structure predictions are available.
    2 View Details [128..306] PSI-BLAST 92.0 pbx1

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • transcription regulator activity
    		•  5.13863038737912 bayes_pls_golite062009
  • DNA binding
    		•  4.66369707598026 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.20953772435302 bayes_pls_golite062009
  • transcription factor activity
    		•  4.06706589695599 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  3.16896789933192 bayes_pls_golite062009
  • binding
    		•  3.02779747447702 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.41271657675151 bayes_pls_golite062009
  • general RNA polymerase II transcription factor activity
    		•  2.37652234273616 bayes_pls_golite062009
  • transcription repressor activity
    		•  1.91962622287073 bayes_pls_golite062009
  • transcription activator activity
    		•  1.77700860354597 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  1.73068440195944 bayes_pls_golite062009
  • transcription factor binding
    		•  1.40653841901929 bayes_pls_golite062009
  • chromatin binding
    		•  0.876241359231159 bayes_pls_golite062009
  • transcription cofactor activity
    		•  0.84983974758882 bayes_pls_golite062009
  • protein binding
    		•  0.830419844171551 bayes_pls_golite062009
  • transcription corepressor activity
    		•  0.25931464844298 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle