Protein Overview: SUR1

General Information:
Name(s) found:	SUR1 / YPL057C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|976268\|dbj\|BAA05628.1\| Bcl21p (multicopy suppressor) [Saccharomyces cerevisiae] [NCBI NR] gi\|6325200\|ref\|NP_015268.1\| Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; Sur1p [Saccha [NCBI NR] pir\|\|S41798 SUR1 protein - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|464822\|sp\|P33300.1\|SUR1_YEAST RecName: Full=Mannosyl phosphorylinositol ceramide synthase SUR1 [NCBI NR] gi\|311163\|gb\|AAA68909.1\| SUR1 [Saccharomyces cerevisiae] [NCBI NR] gi\|1079685\|gb\|AAB68308.1\| Sur1p: Multicopy suppressor of cls2-2 and rvs161 [Saccharomyces cerevisiae] [NCBI NR] Mannosyl phosphorylinositol ceramide synthase SUR1 OS=Saccharomyces cerevisiae GN=SUR1 PE=1 SV=1 [Swiss-Prot] SUR1 Protein required for mannosylation of sphingolipids [mips] Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p [SGD] (P33300) SUR1 protein [4932.FASTACCERV.txt] Chr XVI from 453052-451904, reverse complement [hmr_yeast5_DM3-1_pombe.fasta] Chr XVI from 451904-453052, reverse complement [yeastorf3.fasta] SUR1, Chr XVI from 451904-453052, reverse complement [yeast_orfs2] SUR1 SGDID:S0005978, Chr XVI from 453052-451904, reverse complement, Verified ORF [yeastflysequest.fasta] SUR1 SGDID:S0005978, Chr XVI from 453054-451906, reverse complement, Verified ORF [10112005cervSGD.fasta] Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p [Saccharomyces cerevisiae]gi\|464822\|sp\|P3 [nrdb_11152004_Chlamydomonas] SUR1 SGDID:S000005978, Chr XVI from 453054-451906, reverse complement, Verified ORF, "Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid bio [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Bcl21p (multicopy suppressor) [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; Sur1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] SUR1 gene product [nr-271106-contam.fasta] Sur1p: Multicopy suppressor of cls2-2 and rvs161 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Mannosyl phosphorylinositol ceramide synthase SUR1 [nr-271106-contam.fasta] SUR1 SGDID:S000005978, Chr XVI from 453054-451906, reverse complement, Verified ORF, "Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Mannosyl phosphorylinositol ceramide synthase SUR1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SUR1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] SUR1 SGDID:S000005978, Chr XVI from 453057-451909, Genome Release 64-1-1, reverse complement, Verified ORF, "Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p" [yeast-030211-contam.fasta] SUR1 SGDID:S000005978, Chr XVI from 453057-451909, Genome Release 64-2-1, reverse complement, Verified ORF, "Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication" [20141208_orf_trans.fasta] YPL057C SGDID:S000005978, Chr XVI from 453057-451909, Genome Release 64-1-1, reverse complement, Verified ORF, "Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	382 amino acids
Gene Ontology:
Cellular Component:	intracellular [IC]
Biological Process:	glycosphingolipid biosynthetic process [IMP][ISS] mannose inositol phosphoceramide metabolic process [IMP] sphingolipid biosynthetic process [IMP][TAS]
Molecular Function:	transferase activity, transferring glycosyl groups [ISS] mannosyltransferase activity [IGI][IMP]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRKELKYLIC FNILLLLSII YYTFDLLTLC IDDTVKDAIL EEDLNPDAPP KPQLIPKIIH  60
   61 QTYKTEDIPE HWKEGRQKCL DLHPDYKYIL WTDEMAYEFI KEEYPWFLDT FENYKYPIER 120
  121 ADAIRYFILS HYGGVYIDLD DGCERKLDPL LAFPAFLRKT SPLGVSNDVM GSVPRHPFFL 180
  181 KALKSLKHYD KYWFIPYMTI MGSTGPLFLS VIWKQYKRWR IPKNGTVRIL QPAYYKMHSY 240
  241 SFFSITKGSS WHLDDAKLMK ALENHILSCV VTGFIFGFFI LYGEFTFYCW LCSKNFSNLT 300
  301 KNWKLNAIKV RFVTILNSLG LRLKLSKSTS DTASATLLAR QQKRLRKDSN TNIVLLKSSR 360
  361 KSDVYDLEKN DSSKYSLGNN SS

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	ZDS1	Sample zds1 from august 2005	McCusker D, et al (2007)
View Run	MLP2	#20 Asynchronous Prep1-TiO2 Phosphopeptide enrichment, PartB	Keck JM, et al. (2011)
View Run	MLP2	#32 Asynchronous Prep-No Phosphopeptide enrichment	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	CAB2	SUR1	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	SUR1	Huh WK, et al. (2003)

Protein Structure Data

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Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..82]	MSA	1.092994	View MSA. No confident structure predictions are available.
2	View Details	[83..247]	Pfam	29.136677	No description for PF04488.3 was found. No confident structure predictions are available.
3	View Details	[248..382]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	pre 2.0c	PSIPRED	pre v2.61
SignalP	pre 3.0	COILS	1999
DISOPRED	pre v0.2	NCBI nr	circa 2005
PSI-BLAST	~2.2.10	FFAS	ffas
PDB	~2005	Pfam	16
HMMER	2.3.1