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Protein Overview: RDR1

General Information:
Name(s) found: RDR1 / YOR380W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 546 amino acids

    Gene Ontology:
    Cellular Component: nucleus [TASLink to PubMed article]
    Biological Process: response to xenobiotic stimulus [IMPLink to PubMed article]
    Molecular Function: transcription factor activity [IGILink to PubMed article][IMPLink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MASPGSTALP HKRQRVRKAC VPCRERKRKC NGKSPCEMCV AYGYVCHYID GRVPSASPQV  60
   61 QQVGETSPDT ESRPFVLPGI HRNEQPQPIN TQNVTSQNIV DPTKSRYTIQ HSAVAFPRCL 120
  121 GLELRSTNPP RLHSFAWHCG IRPEENPNSH VLLSDLVTKE EYYRISKVYF SVVHPIFDVV 180
  181 NPEQLAKNVE KYWDGDVKTL EYGAVIAGVI ALGSFFMGSL GHPREMDIVQ YAKGILDDPT 240
  241 FSRIPTVEQV SAWVLRTIYL RATSRPHVAW LASCVTIHLS EAIGLHHEID REDIAISNNV 300
  301 PPKRTTVVSE HTRRLFWCAW SINTILSYDY GRSSVTLNRI TCKPVKETDG NFTAHLVALA 360
  361 HLIPQDSVNA NAAQLLQALA AVHESPNAHP FLSLTKGDIC LSLYRRLRLL NHILDKNVVL 420
  421 QIIDIGNTAL SAAYALVKLD QAWWNVLSTS FQYVCVLLAI DTPESLSHVA TAMKTLDNIT 480
  481 QILGTRIAFE AQKTAKLLLE DSMKKKRQEI QQLEQATHQR SNLETTHLLD IDWDALLDPS 540
  541 DTLNFM

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) NSA1 PMS1 RDR1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #26 Asynchronous Prep4-TiO2 Phosphopeptide enriched, Steps1-2 Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..99] PSI-BLAST 36.0 PUT3
    2 View Details [100..546] MSA 9.232982 View MSA. No confident structure predictions are available.
    3 View Details [223..351] Pfam 19.568636 No description for PF04082.9 was found. No confident structure predictions are available.
    4 View Details [352..546] MSA 4.393996 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  2.36540182658818 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.82012686871762 bayes_pls_golite062009
  • DNA binding
    		•  1.78629392205727 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.70162817919532 bayes_pls_golite062009
  • transcription factor activity
    		•  0.606922041618269 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  0.160255273911114 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  0.0882387940255902 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.74

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle