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Protein Overview: GPB1

General Information:
Name(s) found: GPB1 / YOR371C [SGD]
Description(s) found:
Found 28 descriptions.
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  • Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb2p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 897 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    plasma membrane [IGILink to PubMed article]
    Biological Process: filamentous growth [IGILink to PubMed article]
    negative regulation of Ras protein signal transduction [IGILink to PubMed article]
    signal transduction [IPILink to PubMed article]
    invasive growth in response to glucose limitation [IGILink to PubMed article]
    negative regulation of phosphorylation [IGILink to PubMed article]
    Molecular Function: GTPase activating protein binding [IPILink to PubMed article]
    protein kinase inhibitor activity [IGILink to PubMed article]
    signal transducer activity [IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPQASTFGSH SLEAHPLHIQ PAVHIKLSKE ERSHYREQYD SLKYISNYVS VFDQALSDNI  60
   61 DSRIRKENEA LLKKYYESRK PFTFTSFRQG SVISSSDSST GFTERTKTYC FLNDFVSNCV 120
  121 NEVDPYTLKM TVRNRNTALN MENLDDERKS KDDIYDFEDN TDDECNAKCH GAFHYSSERL 180
  181 EILRSRSTIS YFKYYKKLLT VDLRDSDVLK RHNLWMPMIT RRFRFLLVSS SKPEDVRLTT 240
  241 PIPTFSESDL DIFKNKTCPL FINGTDCVPR SYDTFSGSSV IASIFSEYKL PSLSYHCSVE 300
  301 LNDQLFIVGG LMACHRYDEE APDLKDFYVD GIKNLPPPLI PELINNPSMI PNPHLYCFSL 360
  361 TSSRLTRPDI SGYIPPPLVC TQGCKLTERH IFLYGGFEIK SETQVDDKGR YFIRKRAFLN 420
  421 NTGYILDTVT FNFSKIELVA PPYQFAIYNN FSPRFGHMQA SISNSNNNVS NENTTTSAKG 480
  481 RRSISPYRQG NGDHKIDDLV GSPGSTDYLE DDAIPPVTNP RSTDSLSSKH CSTATHICSS 540
  541 VNTILIFGGY SQTGDDKYEA MNDMWKINIP VVSRGKRNYY KFADTVTATK IPIIDDPELW 600
  601 PSRRAFSACC VPDYFTKDVE PIETRLLRNL KNDFSIDLEI RPGNKPSQPL FPNIPHSRKE 660
  661 KKSGRDSMHI SNSNNSTSED TSSKSTRNTT SSPPTSPKHT PPLNPSKKCA SIGRTIAFHG 720
  721 GSDGYDVCSD MWWFDFDSET WTKIDLYAKT QEESDGLVPI NLCMVGHSMT TVGHKVVLIG 780
  781 GLRQGDVDRI YRDETLPEEV ISGVPLGSGV INVVDLNTQC LQGCKLIRND GDTKESVIMD 840
  841 PHVGTPHQVL AVAGTIELVK GTMTLIGGVV AGREDISSLY LRGAVLQFIL PSMNLAN

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) GPB1 GPB2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data GPB1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..645] deduced N/A No confident structure predictions are available.
    2 View Details [646..794] MSA 1.003997 View MSA. No confident structure predictions are available.
    3 View Details [795..897] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.96

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle