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Protein Overview: PYK2

General Information:
Name(s) found: PYK2 / YOR347C [SGD]
Description(s) found:
Found 26 descriptions.
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  • Pyruvate kinase that appears to be modulated by phosphorylation; PYK2 transcription is repressed by glucose, and Pyk2p may be active under low glycolytic flux [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 506 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed article]
    cytosol [TAS]
    Biological Process: pyruvate metabolic process [IMPLink to PubMed article]
    Molecular Function: pyruvate kinase activity [IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPESRLQRLA NLKIGTPQQL RRTSIIGTIG PKTNSCEAIT ALRKAGLNII RLNFSHGSYE  60
   61 FHQSVIENAV KSEQQFPGRP LAIALDTKGP EIRTGRTLND QDLYIPVDHQ MIFTTDASFA 120
  121 NTSNDKIMYI DYANLTKVIV PGRFIYVDDG ILSFKVLQII DESNLRVQAV NSGYIASHKG 180
  181 VNLPNTDVDL PPLSAKDMKD LQFGVRNGIH IVFASFIRTS EDVLSIRKAL GSEGQDIKII 240
  241 SKIENQQGLD NFDEILEVTD GVMIARGDLG IEILAPEVLA IQKKLIAKCN LAGKPVICAT 300
  301 QMLDSMTHNP RPTRAEVSDV GNAVLDGADC VMLSGETAKG DYPVNAVNIM AATALIAEST 360
  361 IAHLALYDDL RDATPKPTST TETVAAAATA AILEQDGKAI VVLSTTGNTA RLLSKYRPSC 420
  421 PIILVTRHAR TARIAHLYRG VFPFLYEPKR LDDWGEDVHR RLKFGVEMAR SFGMVDNGDT 480
  481 VVSIQGFKGG VGHSNTLRIS TVGQEF

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details (MIPS) Mewes HW, et al. (2004) CDC19 PYK2
    View Details Krogan NJ, et al. (2006) MSS51 PYK2 SSC1
    View Details Gavin AC, et al. (2006) MRS6 PYK2

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run PSF2 No Comments Hazbun TR, et al. (2003)
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run VAM3 Sample: HX11 - both fusion and trans-SNARE complex formation take place. Hao Xu, et al. (2010)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PYK2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..91]
    [188..362]    		 PSI-BLAST 11000.0 Pyruvate kinase (PK); Pyruvate kinase, N-terminal domain; Pyruvate kinase, C-terminal domain
    2 View Details [92..187]
    [363..506]    		 PSI-BLAST 11000.0 Pyruvate kinase (PK); Pyruvate kinase, N-terminal domain; Pyruvate kinase, C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • pyruvate kinase activity
    		•  5.30539631424432 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  3.74686803828771 bayes_pls_golite062009
  • kinase activity
    		•  3.60311146880852 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  3.2602140947877 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  2.49386405838309 bayes_pls_golite062009
  • transferase activity
    		•  2.39042747917065 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  2.35681897894387 bayes_pls_golite062009
  • hydroxymethyl-, formyl- and related transferase activity
    		•  1.41686595651633 bayes_pls_golite062009
  • binding
    		•  1.40856686140554 bayes_pls_golite062009
  • ADP binding
    		•  1.23883289666587 bayes_pls_golite062009
  • glycine hydroxymethyltransferase activity
    		•  1.09759860844913 bayes_pls_golite062009
  • hydrolase activity
    		•  0.962445116339459 bayes_pls_golite062009
  • catalytic activity
    		•  0.932947046865376 bayes_pls_golite062009
  • phosphoenolpyruvate carboxykinase activity
    		•  0.777178963260734 bayes_pls_golite062009
  • protein binding
    		•  0.438735017993357 bayes_pls_golite062009
  • lyase activity
    		•  0.0456521871650777 bayes_pls_golite062009
  • phosphotransferase activity, paired acceptors
    		•  0.0254711315719321 bayes_pls_golite062009
  • citrate (pro-3S)-lyase activity
    		•  0.0039163158887896 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle