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Protein Overview: ORT1

General Information:
Name(s) found: ORT1 / YOR130C [SGD]
Description(s) found:
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  • gi|6324704|ref|NP_014773.1| Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndr [NCBI NR]
  • gi|2497988|sp|Q12375.1|ORT1_YEAST RecName: Full=Mitochondrial ornithine carrier protein [NCBI NR]
  • pir||S60997 ARG11 protein - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1420336|emb|CAA99329.1| ARG11 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1164974|emb|CAA64049.1| YOR3299c [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1050823|emb|CAA62118.1| ORF O3299 [Saccharomyces cerevisiae] [NCBI NR]
  • Mitochondrial ornithine carrier protein OS=Saccharomyces cerevisiae GN=ORT1 PE=1 SV=1 [Swiss-Prot]
  • ORT1 Mitochondrial ornithine carrier - member of the mitochondrial carrier (MCF) family [mips]
  • Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome [SGD]
  • (Q12375) Mitochondrial ornithine carrier protein [4932.FASTACCERV.txt]
  • Chr XV from 570807-569929, reverse complement [hmr_yeast5_DM3-1_pombe.fasta]
  • Chr XV from 569928-570806, reverse complement [yeastorf3.fasta]
  • Chr XV from 569929-570807, reverse complement [yeastorf4.fasta]
  • ORT1, Chr XV from 569928-570806, reverse complement [yeast_orfs2]
  • ORT1 SGDID:S0005656, Chr XV from 570807-569929, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome [Saccharomyces cerevisia [nrdb_11152004_Chlamydomonas]
  • ORT1 SGDID:S000005656, Chr XV from 570807-569929, reverse complement, Verified ORF, "Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperam [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • ORT1 SGDID:S000005656, Chr XV from 570808-569930, reverse complement, Verified ORF, "Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperam [yeast-contam.fasta]
  • YOR3299c [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome; Ort1p [Saccharomyces ce [nr-271106-contam.fasta]
  • ARG11 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Mitochondrial ornithine carrier protein [nr-271106-contam.fasta]
  • ORF O3299 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • ORT1 SGDID:S000005656, Chr XV from 570808-569930, reverse complement, Verified ORF, "Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 292 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial envelope [IDALink to PubMed article]
    Biological Process: mitochondrial ornithine transport [IDALink to PubMed article]
    arginine biosynthetic process [IMPLink to PubMed article]
    Molecular Function: L-ornithine transmembrane transporter activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEDSKKKGLI EGAILDIING SIAGACGKVI EFPFDTVKVR LQTQASNVFP TTWSCIKFTY  60
   61 QNEGIARGFF QGIASPLVGA CLENATLFVS YNQCSKFLEK HTNVFPLGQI LISGGVAGSC 120
  121 ASLVLTPVEL VKCKLQVANL QVASAKTKHT KVLPTIKAII TERGLAGLWQ GQSGTFIRES 180
  181 FGGVAWFATY EIVKKSLKDR HSLDDPKRDE SKIWELLISG GSAGLAFNAS IFPADTVKSV 240
  241 MQTEHISLTN AVKKIFGKFG LKGFYRGLGI TLFRAVPANA AVFYIFETLS AL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ORT1 PET8

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data ORT1 Huh WK, et al. (2003)

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..292] ORFEUS 8.32 Peroxisomal acyl-CoA oxidase-II, domains 3 and 4; Peroxisomal acyl-CoA oxidase-II, domains 1 and 2


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle