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Protein Overview: LEU9

General Information:
Name(s) found: LEU9 / YOR108W [SGD]
Description(s) found:
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  • gi|74645027|sp|Q12166.1|LEU9_YEAST RecName: Full=2-isopropylmalate synthase 2, mitochondrial; AltName: Full=Alpha-isopropylmalate synthase 2; AltName: Full=Alpha-IPM synthetase 2; AltName: Full=Alpha-isopropylmalate synthase II; Flags: Precursor [NCBI NR]
  • gi|6324682|ref|NP_014751.1| Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant; L [NCBI NR]
  • pir||S66993 hypothetical protein YOR108w - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|1420293|emb|CAA99306.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1262141|emb|CAA64028.1| YOR3227w [Saccharomyces cerevisiae] [NCBI NR]
  • 2-isopropylmalate synthase 2, mitochondrial OS=Saccharomyces cerevisiae GN=LEU9 PE=1 SV=1 [Swiss-Prot]
  • LEU9 Alpha-isopropylmalate synthase II, catalyzes the first step in the leucine biosynthesis pathway [mips]
  • Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant [SGD]
  • >Q12166 (Q12166) YOR3227W from chromosome XV [4932.FASTACCERV.txt]
  • Chr XV from 523027-524841 [hmr_yeast5_DM3-1_pombe.fasta]
  • Chr XV from 523026-524840 [yeastorf3.fasta]
  • YOR108W, Chr XV from 523026-524840 [yeast_orfs2]
  • LEU9 SGDID:S0005634, Chr XV from 523027-524841, Verified ORF [yeastflysequest.fasta]
  • Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant [Saccharomyces cerevisiae]gi| [nrdb_11152004_Chlamydomonas]
  • (Q12166) YOR3227w protein (S.cerevisiae chromosome XV reading frame ORF YOR108w) [cerv4932.FASTAC]
  • LEU9 SGDID:S000005634, Chr XV from 523027-524841, Verified ORF, "Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activ [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • LEU9 SGDID:S000005634, Chr XV from 523028-524842, Verified ORF, "Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activ [yeast-contam.fasta]
  • Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant; Leu9p [Saccharomyces cerevisi [nr-271106-contam.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • YOR3227w [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • LEU9 SGDID:S000005634, Chr XV from 523028-524842, Verified ORF, "Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • 2-isopropylmalate synthase 2, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=LEU9 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • LEU9 SGDID:S000005634, Chr XV from 523027-524841, Genome Release 64-1-1, Verified ORF, "Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant" [yeast-030211-contam.fasta]
  • LEU9 SGDID:S000005634, Chr XV from 523027-524841, Genome Release 64-2-1, Verified ORF, "Alpha-isopropylmalate synthase II (2-isopropylmalate synthase); catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant; LEU9 has a paralog, LEU4, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YOR108W SGDID:S000005634, Chr XV from 523027-524841, Genome Release 64-1-1, Verified ORF, "Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • ID=asmbl_2403|g.1582 ORF ID=asmbl_2403|g.1582 ID=asmbl_2403|m.1582 type:complete len:605 (+) ID=asmbl_2403:129-1943(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 604 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: leucine biosynthetic process [IGILink to PubMed article]
    Molecular Function: 2-isopropylmalate synthase activity [IDALink to PubMed article][IGILink to PubMed article][ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVKHSFIALA EHASKLRRSI PPVKLTYKNM LRDPSVKYRA FAPPKMVKRI WPDKTIQKAP  60
   61 RWLSTDLRDG NQSLPDPMSV AQKKEYFHKL INIGFKEIEV SFPSASQTDF DFTRYAVENA 120
  121 PDDVGIQCLV QSREHLIKRT VEALTGAKRA TIHTYLATSD MFREIVFNMS REEAISKAVE 180
  181 ATKLVRKLTK DDPSQQATRW SYEFSPECFS DTPGEFAVEI CEAVKKAWEP TEENPIIFNL 240
  241 PATVEVASPN VYADQIEYFS THITEREKVC ISTHCHNDRG CGVAATELGM LAGADRVEGC 300
  301 LFGNGERTGN VDLVTVAMNM YTQGVSPNLD FSDLTSISEI VHRCNKIPIP PRAPYGGELV 360
  361 VSAFSGSHQD AIKKGFAIQN KKQAQGETRW RIPYLPLDPK DIGRDYEAVI RVNSQSGKGG 420
  421 AAWVIMRSLG LDVPRPMQVD FSNTLQKNAD ALGRELKSEE ITKLFKETYN YNNNEHIYVT 480
  481 LLNYEVKKLN PERRALVGQV EINDKVVNIE GYGNGPISSL VDALSNLLNV KLSVQNYSEH 540
  541 SLGSGSATQA ASFINLSYIK DINNHATSNM WGVGVSEDTG DASIKAVFAT VNNIIHSGDV 600
  601 LLAE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) LEU4 LEU9
    View Details Krogan NJ, et al. (2006) LEU4 LEU9

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen YHR122W LEU9 1 Hazbun TR, et al. (2003)

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data LEU9 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..52] deduced N/A No confident structure predictions are available.
    2 View Details [53..218] ORFEUS 8.57 KDPG aldolase
    3 View Details [219..490] ORFEUS 7.4 N-acetylneuraminate lyase
    4 View Details [491..604] MSA 1.085992 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • 2-isopropylmalate synthase activity
    		•  3.07962096729216 bayes_pls_golite062009
  • transferase activity, transferring aldehyde or ketonic groups
    		•  2.96685031644778 bayes_pls_golite062009
  • catalytic activity
    		•  2.67031204377352 bayes_pls_golite062009
  • lyase activity
    		•  0.740424046054758 bayes_pls_golite062009
  • porphobilinogen synthase activity
    		•  0.658378297259497 bayes_pls_golite062009
  • transaldolase activity
    		•  0.184100272651834 bayes_pls_golite062009
  • binding
    		•  0.155633578635864 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle