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Protein Overview: PPM2

General Information:
Name(s) found: PPM2 / YOL141W [SGD]
Description(s) found:
Found 22 descriptions.
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  • AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 695 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed articleLink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: C-terminal protein carboxyl methyltransferase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKNLTTIKQT NKNVKQERRK KYADLAIQGT NNSSIASKRS VELLYLPKLS SANNFQMDKN  60
   61 NKLLEYFKFF VPKKIKRSPC INRGYWLRLF AIRSRLNSII EQTPQDKKIV VVNLGCGYDP 120
  121 LPFQLLDTNN IQSQQYHDRV SFIDIDYSDL LKIKIELIKT IPELSKIIGL SEDKDYVDDS 180
  181 NVDFLTTPKY LARPCDLNDS KMFSTLLNEC QLYDPNVVKV FVAEVSLAYM KPERSDSIIE 240
  241 ATSKMENSHF IILEQLIPKG PFEPFSKQML AHFKRNDSPL QSVLKYNTIE SQVQRFNKLG 300
  301 FAYVNVGDMF QLWESADEAT KKELLKVEPF DELEEFHLFC HHYVLCHATN YKEFAFTQGF 360
  361 LFDRSISEIN LTVDEDYQLL ECECPINRKF GDVDVAGNDV FYMGGSNPYR VNEILQMSIH 420
  421 YDKIDMKNIE VSSSEVPVAR MCHTFTTISR NNQLLLIGGR KAPHQGLSDN WIFDMKTREW 480
  481 SMIKSLSHTR FRHSACSLPD GNVLILGGVT EGPAMLLYNV TEEIFKDVTP KDEFFQNSLV 540
  541 SAGLEFDPVS KQGIILGGGF MDQTTVSDKA IIFKYDAENA TEPITVIKKL QHPLFQRYGS 600
  601 QIKYITPRKL LIVGGTSPSG LFDRTNSIIS LDPLSETLTS IPISRRIWED HSLMLAGFSL 660
  661 VSTSMGTIHI IGGGATCYGF GSVTNVGLKL IAIAK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #31 Asynchronous Prep (Protease cleavage) Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PPM2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..363] MSA 19.185981 View MSA. No confident structure predictions are available.
    2 View Details [364..695] PSI-BLAST 10.30103 Galactose oxidase, C-terminal domain; Galactose oxidase, N-terminal domain; Galactose oxidase, central domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein methyltransferase activity
    		•  5.03267617653315 bayes_pls_golite062009
  • methyltransferase activity
    		•  4.15445027778357 bayes_pls_golite062009
  • N-methyltransferase activity
    		•  4.07806017452628 bayes_pls_golite062009
  • transferase activity, transferring one-carbon groups
    		•  4.07153733729662 bayes_pls_golite062009
  • histone methyltransferase activity
    		•  3.97658336148086 bayes_pls_golite062009
  • S-adenosylmethionine-dependent methyltransferase activity
    		•  3.39429041855776 bayes_pls_golite062009
  • protein-arginine N-methyltransferase activity
    		•  3.26663548517117 bayes_pls_golite062009
  • arginine N-methyltransferase activity
    		•  3.26663548517117 bayes_pls_golite062009
  • RNA methyltransferase activity
    		•  3.07428840534971 bayes_pls_golite062009
  • transferase activity
    		•  2.926540904444 bayes_pls_golite062009
  • histone-arginine N-methyltransferase activity
    		•  2.86617323549909 bayes_pls_golite062009
  • tRNA methyltransferase activity
    		•  2.5931020126592 bayes_pls_golite062009
  • rRNA methyltransferase activity
    		•  2.5924681776558 bayes_pls_golite062009
  • protein-arginine omega-N monomethyltransferase activity
    		•  2.48017990451667 bayes_pls_golite062009
  • DNA-methyltransferase activity
    		•  2.18991764495147 bayes_pls_golite062009
  • histone methyltransferase activity (H4-R3 specific)
    		•  1.91133457052099 bayes_pls_golite062009
  • tRNA (cytosine)-methyltransferase activity
    		•  1.88889414729709 bayes_pls_golite062009
  • tRNA (cytosine-5-)-methyltransferase activity
    		•  1.88889414729709 bayes_pls_golite062009
  • protein-arginine omega-N asymmetric methyltransferase activity
    		•  1.69391860928068 bayes_pls_golite062009
  • tRNA (adenine)-methyltransferase activity
    		•  1.29759910099835 bayes_pls_golite062009
  • tRNA (adenine-N1-)-methyltransferase activity
    		•  1.29759910099835 bayes_pls_golite062009
  • catalytic activity
    		•  1.25333584501255 bayes_pls_golite062009
  • protein-arginine omega-N symmetric methyltransferase activity
    		•  1.15089820497406 bayes_pls_golite062009
  • transcription regulator activity
    		•  0.914549843668268 bayes_pls_golite062009
  • DNA binding
    		•  0.86027591375666 bayes_pls_golite062009
  • rRNA (adenine) methyltransferase activity
    		•  0.794703281700029 bayes_pls_golite062009
  • rRNA (adenine-N6,N6-)-dimethyltransferase activity
    		•  0.716476158062361 bayes_pls_golite062009
  • site-specific DNA-methyltransferase (adenine-specific) activity
    		•  0.703178429468566 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.616949327277483 bayes_pls_golite062009
  • histone-lysine N-methyltransferase activity
    		•  0.469870476227704 bayes_pls_golite062009
  • protein-lysine N-methyltransferase activity
    		•  0.469870476227704 bayes_pls_golite062009
  • lysine N-methyltransferase activity
    		•  0.469870476227704 bayes_pls_golite062009
  • RNA binding
    		•  0.417524996559564 bayes_pls_golite062009
  • binding
    		•  0.383237930789959 bayes_pls_golite062009
  • tRNA (guanine) methyltransferase activity
    		•  0.203168546434167 bayes_pls_golite062009
  • rRNA (guanine) methyltransferase activity
    		•  0.0854264678700428 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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