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Protein Overview: HMI1

General Information:
Name(s) found: HMI1 / YOL095C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 706 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [IDALink to PubMed article]
    mitochondrion [IDALink to PubMed article]
    Biological Process: mitochondrial DNA metabolic process [IMPLink to PubMed article]
    mitochondrial genome maintenance [IMPLink to PubMed article]
    Molecular Function: ATP-dependent 3'-5' DNA helicase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDKLTPSQWK VINKSYEPAS TIKVIAGPGS GKTLTLLYKV LHLITVENIK PEEILIFSLT  60
   61 NKAVDSIIEN LLSIFENSHT NKEIVHQIGC YTVHGLANRI VVENEGMINI IEEIGWRGLM 120
  121 KLLPPSKRTP HHFRSYKELE KVVKDYKLNN AKNNNPVIEK LVELMDNCKV MTNDDLIIRA 180
  181 KKYLELDSSD SDASSFTQDL RNKYKVVLID EFQDLYPSLA PLITMICKGK QLIMFGDTNQ 240
  241 SIYGFLGSNN EIMSQLDNLH PKNSTTVLKL FDNFRSTPEI ISLASKIINR PLAEKQIIDD 300
  301 TDETPSELVR KLPSGVSPQI MTFDDLAAES EFIIDKITQL ICSSAKFSDI AILSRTNSHL 360
  361 TAIASILKKY GIPYQKLKSQ PDWMDDLRIQ FLLDILKVCS LASDEKHNRE FNTGDKWQSN 420
  421 FSILVTMSAL KGIGDASIQA LYKACSLKNL SIWKYLTMVP NFEWPLGLSI KKKMENYTSN 480
  481 LYEMIENDQV HQLDDPMELL EKVASITNNL NLNPTYFQSL SDAQSSLEFK THLQEMAQVM 540
  541 KVSKSNKPPG ISFVKWFLET YFDQTMVFHQ SQQALQTTGP GTVKLSTIHS AKGLEFPIVF 600
  601 LTNGSMSNFP MDTNALYVGI TRARNLLYMC NMKHERLVSK SSPYSRNIMS NNLFWTYYNK 660
  661 DLKRSVCDVK VTHGYNVQRY NQLRKNFGFY RAYSSLRGCK SVFRRI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #14 Mitotic Prep2-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..274] PSI-BLAST 362.0 DEXX box DNA helicase
    2 View Details [275..706] PSI-BLAST 362.0 DEXX box DNA helicase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle