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Protein Overview: SEC12

General Information:
Name(s) found: SEC12 / YNR026C [SGD]
Description(s) found:
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  • pir||A31103 membrane glycoprotein SEC12 - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|6324353|ref|NP_014423.1| Guanine nucleotide exchange factor (GEF); glycosylated integral membrane protein of the endoplasmic reticulum, important for the initiation of transport vesicle budding from the endoplasmic reticulum through activation of the G [NCBI NR]
  • gi|4435|emb|CAA31559.1| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR]
  • gi|134263|sp|P11655.1|SEC12_YEAST RecName: Full=Guanine nucleotide-exchange factor SEC12; AltName: Full=Protein transport protein SEC12 [NCBI NR]
  • gi|1302517|emb|CAA96306.1| SEC12 [Saccharomyces cerevisiae] [NCBI NR]
  • Guanine nucleotide-exchange factor SEC12 OS=Saccharomyces cerevisiae GN=SEC12 PE=1 SV=1 [Swiss-Prot]
  • (P11655) Membrane glycoprotein SEC12 [Swiss-Prot]
  • SEC12 GDP/GTP exchange factor for Sar1p [mips]
  • Guanine nucleotide exchange factor (GEF), activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER [SGD]
  • Chr XIV from 674686-673271, reverse complement [hmr_yeast5_DM3-1_pombe.fasta]
  • Chr XIV from 673271-674686, reverse complement [yeastorf3.fasta]
  • SEC12, Chr XIV from 673271-674686, reverse complement [yeast_orfs2]
  • SEC12 SGDID:S0005309, Chr XIV from 674688-673273, reverse complement, Verified ORF [yeastflysequest.fasta]
  • SEC12 SGDID:S0005309, Chr XIV from 674689-673274, reverse complement, Verified ORF [10112005cervSGD.fasta]
  • Guanine nucleotide exchange factor (GEF); glycosylated integral membrane protein of the endoplasmic reticulum, important for the initiation of transport vesicle budding from the endoplasmic reticulum through activation of the GTPase Sar1p [Saccharomyces c [nrdb_11152004_Chlamydomonas]
  • SEC12 SGDID:S000005309, Chr XIV from 674691-673276, reverse complement, Verified ORF, "Guanine nucleotide exchange factor (GEF); glycosylated integral membrane protein of the endoplasmic reticulum, important for the initiation of transport vesicle budding [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Guanine nucleotide exchange factor (GEF); glycosylated integral membrane protein of the endoplasmic reticulum, important for the initiation of transport vesicle budding from the endoplasmic reticulum through activation of the GTPase Sar1p; Sec12p [Sacchar [nr-271106-contam.fasta]
  • Membrane glycoprotein SEC12 [nr-271106-contam.fasta]
  • SEC12 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • SEC12 SGDID:S000005309, Chr XIV from 674692-673277, reverse complement, Verified ORF, "Guanine nucleotide exchange factor (GEF); glycosylated integral membrane protein of the endoplasmic reticulum, important for the initiation of transport vesicle budding [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta]
  • SEC12 SGDID:S000005309, Chr XIV from 674691-673276, reverse complement, Verified ORF, "Guanine nucleotide exchange factor (GEF); glycosylated integral membrane protein of the endoplasmic reticulum, important for the initiation of transport vesicle budding from the endoplasmic reticulum through activation of the GTPase Sar1p" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • SEC12 SGDID:S000005309, Chr XIV from 674692-673277, reverse complement, Verified ORF, "Guanine nucleotide exchange factor (GEF); glycosylated integral membrane protein of the endoplasmic reticulum, important for the initiation of transport vesicle budding from the endoplasmic reticulum through activation of the GTPase Sar1p" [SGDyeast.20101221.fasta]
  • Guanine nucleotide-exchange factor SEC12 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SEC12 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • SEC12 SGDID:S000005309, Chr XIV from 674689-673274, Genome Release 64-1-1, reverse complement, Verified ORF, "Guanine nucleotide exchange factor (GEF), activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER" [yeast-030211-contam.fasta]
  • SEC12 SGDID:S000005309, Chr XIV from 674689-673274, Genome Release 64-2-1, reverse complement, Verified ORF, "Guanine nucleotide exchange factor (GEF); activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER; SEC12 has a paralog, SED4, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
  • YNR026C SGDID:S000005309, Chr XIV from 674689-673274, Genome Release 64-1-1, reverse complement, Verified ORF, "Guanine nucleotide exchange factor (GEF), activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 471 amino acids

    Gene Ontology:
    Cellular Component: integral to endoplasmic reticulum membrane [IDALink to PubMed article]
    integral to membrane of membrane fraction [IDALink to PubMed article]
    Biological Process: ER to Golgi vesicle-mediated transport [IDALink to PubMed article]
    ER-associated protein catabolic process [IMPLink to PubMed article]
    Molecular Function: guanyl-nucleotide exchange factor activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKFVTASYNV GYPAYGAKFL NNDTLLVAGG GGEGNNGIPN KLTVLRVDPT KDTEKEQFHI  60
   61 LSEFALEDND DSPTAIDASK GIILVGCNEN STKITQGKGN KHLRKFKYDK VNDQLEFLTS 120
  121 VDFDASTNAD DYTKLVYISR EGTVAAIASS KVPAIMRIID PSDLTEKFEI ETRGEVKDLH 180
  181 FSTDGKVVAY ITGSSLEVIS TVTGSCIARK TDFDKNWSLS KINFIADDTV LIAASLKKGK 240
  241 GIVLTKISIK SGNTSVLRSK QVTNRFKGIT SMDVDMKGEL AVLASNDNSI ALVKLKDLSM 300
  301 SKIFKQAHSF AITEVTISPD STYVASVSAA NTIHIIKLPL NYANYTSMKQ KISKFFTNFI 360
  361 LIVLLSYILQ FSYKHNLHSM LFNYAKDNFL TKRDTISSPY VVDEDLHQTT LFGNHGTKTS 420
  421 VPSVDSIKVH GVHETSSVNG TEVLCTESNI INTGGAEFEI TNATFREIDD A

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) SBH1 SEC12 SOP4 YOS1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SEC12 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..337] PSI-BLAST 68.154902 beta1-subunit of the signal-transducing G protein heterotrimer
    2 View Details [338..471] PSI-BLAST 26.30103 Groucho/tle1, C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • protein binding
    		•  1.61720914342874 bayes_pls_golite062009
  • binding
    		•  1.40353148474598 bayes_pls_golite062009
  • transporter activity
    		•  1.21549336905926 bayes_pls_golite062009
  • ubiquitin-protein ligase activity
    		•  0.949459052802047 bayes_pls_golite062009
  • small conjugating protein ligase activity
    		•  0.876326238093745 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.734793983890004 bayes_pls_golite062009
  • protein transporter activity
    		•  0.304681243699511 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.110806113669931 bayes_pls_golite062009
  • acid-amino acid ligase activity
    		•  0.0294947647335083 bayes_pls_golite062009
  • hydrolase activity
    		•  0.0078918747815433 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.51

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle