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Protein Overview: VPS27

General Information:
Name(s) found: VPS27 / YNR006W [SGD]
Description(s) found:
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  • gi|6324332|ref|NP_014403.1| Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiqui [NCBI NR]
  • pir||S45129 VPS27 protein - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • gi|496723|emb|CAA54574.1| N2038 [Saccharomyces cerevisiae] [NCBI NR]
  • gi|1302478|emb|CAA96282.1| VPS27 [Saccharomyces cerevisiae] [NCBI NR]
  • VPS27 Vacuolar protein sorting-associated protein [mips]
  • Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p) [SGD]
  • Chr XIV from 636983-638851 [yeastorf5.fasta]
  • VPS27, Chr XIV from 636983-638851 [yeast_orfs2]
  • VPS27 SGDID:S0005289, Chr XIV from 636985-638853, Verified ORF [yeastflysequest.fasta]
  • VPS27 SGDID:S0005289, Chr XIV from 636986-638854, Verified ORF [10112005cervSGD.fasta]
  • Vps27p [Saccharomyces cerevisiae]gi|1302478|emb|CAA96282.1| VPS27 [Saccharomyces cerevisiae]gi|496723|emb|CAA54574.1| N2038 [Saccharomyces cerevisiae]gi|626464|pir||S45129 VPS27 protein - yeast (Saccharomyces cerevisiae) [nrdb_11152004_Chlamydomonas]
  • VPS27 SGDID:S000005289, Chr XIV from 636988-638856, Verified ORF, "Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquit [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • N2038 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • VPS27 [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p); Vps27p [Sacchar [nr-271106-contam.fasta]
  • VPS27 SGDID:S000005289, Chr XIV from 636989-638857, Verified ORF, "Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquit [SGD_S-cerevisiae_na_01-05-2010_reversed.fasta]
  • VPS27 SGDID:S000005289, Chr XIV from 636988-638856, Verified ORF, "Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • VPS27 SGDID:S000005289, Chr XIV from 636989-638857, Verified ORF, "Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)" [SGDyeast.20101221.fasta]
  • Vacuolar protein sorting-associated protein 27 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VPS27 PE=1 SV=3 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • VPS27 SGDID:S000005289, Chr XIV from 636986-638854, Genome Release 64-1-1, Verified ORF, "Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)" [yeast-030211-contam.fasta]
  • VPS27 SGDID:S000005289, Chr XIV from 636986-638854, Genome Release 64-2-1, Verified ORF, "Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)" [20141208_orf_trans.fasta]
  • YNR006W SGDID:S000005289, Chr XIV from 636986-638854, Genome Release 64-1-1, Verified ORF, "Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p)" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 622 amino acids

    Gene Ontology:
    Cellular Component: endosome [IDALink to PubMed article]
    Biological Process: protein targeting [TASLink to PubMed article]
    protein retention in Golgi apparatus [IMPLink to PubMed article]
    endosome transport [IMPLink to PubMed article]
    Molecular Function: protein binding [IDALink to PubMed article]
    phosphatidylinositol-3-phosphate binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVSTPSELD ALIEQATSES IPNGDLDLPI ALEISDVLRS RRVNPKDSMR CIKKRILNTA  60
   61 DNPNTQLSSW KLTNICVKNG GTPFIKEICS REFMDTMEHV ILREDSNEEL SELVKTILYE 120
  121 LYVAFKNDSQ LNYVAKVYDK LISRGIKFPE KLTLSNSPTA MFDSKTPADW IDSDACMICS 180
  181 KKFSLLNRKH HCRSCGGVFC QEHSSNSIPL PDLGIYEPVR VCDSCFEDYD LKRHDDSKKS 240
  241 KKHRHKRKKD RDYSTPEDEE ELIRKAIELS LKESRNSASS EPIVPVVESK NEVKRQEIEE 300
  301 EEDPDLKAAI QESLREAEEA KLRSERQKAS RQMQPQQPSP QPQPIHSVDL SDEEKDSIYM 360
  361 FASLVEKMKS RPLNEILEDS KLQNLAQRVF ASKARLNYAL NDKAQKYNTL IEMNGKISEI 420
  421 MNIYDRLLEQ QLQSINLSQQ YTLPQVPSDP YNYLTENVQN PAESYQTPPL QQLSSHQYKP 480
  481 QQDVSRQQSV KANSSPTTNI DHLKTIDVTP HAQQKPQSHV ELAPSDPPYP KEEAEDEGTQ 540
  541 AVQDEESSTQ ESRERPYPVE TENGETSINK RPQGITRYDF PTVPARKFVQ PESTVPLPAS 600
  601 SSEIPIKEER PPSPQEELLI EL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) HSE1 VPS27
    View Details Krogan NJ, et al. (2006) HSE1 VPS27
    View Details Gavin AC, et al. (2006) HSE1 VPS27
    View Details Gavin AC, et al. (2002) HSE1 VPS27
    View Details Qiu et al. (2008) DID4 VPS27

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data VPS27 Huh WK, et al. (2003)
    View Data VPS27 and SNF7 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..146] ORFEUS 9.55 Clathrin assembly lymphoid myeloid leukaemia protein, Calm
    2 View Details [147..243] PSI-BLAST 401.69897 vps27p protein
    3 View Details [244..356] deduced N/A No confident structure predictions are available.
    4 View Details [357..622] ORFEUS 14.12 No description for 1ldvA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • nucleic acid binding
    		•  0.107173543930241 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle