YRC Public Data Repository - Protein Structure Prediction

Protein:	VPS27
Organism:	Saccharomyces cerevisiae
Length:	622 amino acids
Reference:	Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VPS27.

Description	E-value	Query Range	Subject Range
gi\|1353233, gi\|7... - gi\|785067\|gb\|AAA96002.1\| Vps27p, gi\|1353233\|sp\|P40343.2\|VPS27_YEAST RecName: Full=Vacuolar protein s...	0.0	[1..622]	[1..622]
gi\|1885385 - gi\|1885385\|gb\|AAB49681.1\| SNAP-25 interacting protein hrs-2 [Rattus norvegicus]	0.0	[1..556]	[1..559]
gi\|31982286, gi\|... - gi\|31982286\|ref\|NP_032270.2\| HGF-regulated tyrosine kinase substrate [Mus musculus], gi\|13096878\|gb\|...	0.0	[1..556]	[1..559]
gi\|123998173, gi... - gi\|61362462\|gb\|AAX42226.1\| hepatocyte growth factor-regulated tyrosine kinase substrate [synthetic c... HGS - hepatocyte growth factor-regulated tyrosine kinase substrate	0.0	[1..556]	[1..561]
vps27 - sorting receptor for ubiquitinated membrane proteins, ESCRT 0 complex VPS27_SCHPO - Vacuolar protein sorting-associated protein 27 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843...	8.0E-84	[5..434]	[7..453]
gi\|15088545 - gi\|15088545\|gb\|AAK84081.1\|AF326781_2 putative chromosome condensation factor [Triticum monococcum]	1.0E-66	[163..517]	[418..785]
gi\|7488217, gi\|7... - pir\|\|F71405 probable TMV resistance protein - Arabidopsis thaliana, gi\|7268142\|emb\|CAB78479.1\| dise...	2.0E-65	[140..558]	[1503..1889]
Hrs-PA - The gene Hepatocyte growth factor regulated tyrosine kinase substrate is referred to in FlyBase by t...	7.0E-61	[136..556]	[15..418]

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Predicted Domain #1

Region A:
Residues: [1-146]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSVSTPSELD ALIEQATSES IPNGDLDLPI ALEISDVLRS RRVNPKDSMR CIKKRILNTA  60
   61 DNPNTQLSSW KLTNICVKNG GTPFIKEICS REFMDTMEHV ILREDSNEEL SELVKTILYE 120
  121 LYVAFKNDSQ LNYVAKVYDK LISRGI

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	9.55
Match:	1hf8A
Description:	Clathrin assembly lymphoid myeloid leukaemia protein, Calm
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
nucleic acid binding	0.107173543930241	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [147-243]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KFPEKLTLSN SPTAMFDSKT PADWIDSDAC MICSKKFSLL NRKHHCRSCG GVFCQEHSSN  60
   61 SIPLPDLGIY EPVRVCDSCF EDYDLKRHDD SKKSKKH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	401.69897
Match:	1vfyA_
Description:	vps27p protein
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [244-356]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RHKRKKDRDY STPEDEEELI RKAIELSLKE SRNSASSEPI VPVVESKNEV KRQEIEEEED  60
   61 PDLKAAIQES LREAEEAKLR SERQKASRQM QPQQPSPQPQ PIHSVDLSDE EKD

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [357-622]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SIYMFASLVE KMKSRPLNEI LEDSKLQNLA QRVFASKARL NYALNDKAQK YNTLIEMNGK  60
   61 ISEIMNIYDR LLEQQLQSIN LSQQYTLPQV PSDPYNYLTE NVQNPAESYQ TPPLQQLSSH 120
  121 QYKPQQDVSR QQSVKANSSP TTNIDHLKTI DVTPHAQQKP QSHVELAPSD PPYPKEEAED 180
  181 EGTQAVQDEE SSTQESRERP YPVETENGET SINKRPQGIT RYDFPTVPAR KFVQPESTVP 240
  241 LPASSSEIPI KEERPPSPQE ELLIEL

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	14.12
Match:	1ldvA
Description:	No description for 1ldvA was found.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: