YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: ZWF1

General Information:
Name(s) found: ZWF1 / YNL241C [SGD]
Description(s) found:
Found 26 descriptions.
SHOW ALL
  • Glucose-6-phosphate dehydrogenase (G6PD), catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 505 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed articleLink to PubMed article]
    Biological Process: pentose-phosphate shunt, oxidative branch [ISSLink to PubMed article]
    response to hydrogen peroxide [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: glucose-6-phosphate dehydrogenase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEGPVKFEK NTVISVFGAS GDLAKKKTFP ALFGLFREGY LDPSTKIFGY ARSKLSMEED  60
   61 LKSRVLPHLK KPHGEADDSK VEQFFKMVSY ISGNYDTDEG FDELRTQIEK FEKSANVDVP 120
  121 HRLFYLALPP SVFLTVAKQI KSRVYAENGI TRVIVEKPFG HDLASARELQ KNLGPLFKEE 180
  181 ELYRIDHYLG KELVKNLLVL RFGNQFLNAS WNRDNIQSVQ ISFKERFGTE GRGGYFDSIG 240
  241 IIRDVMQNHL LQIMTLLTME RPVSFDPESI RDEKVKVLKA VAPIDTDDVL LGQYGKSEDG 300
  301 SKPAYVDDDT VDKDSKCVTF AAMTFNIENE RWEGVPIMMR AGKALNESKV EIRLQYKAVA 360
  361 SGVFKDIPNN ELVIRVQPDA AVYLKFNAKT PGLSNATQVT DLNLTYASRY QDFWIPEAYE 420
  421 VLIRDALLGD HSNFVRDDEL DISWGIFTPL LKHIERPDGP TPEIYPYGSR GPKGLKEYMQ 480
  481 KHKYVMPEKH PYAWPVTKPE DTKDN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data ZWF1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..186]
    [416..431]    		 PSI-BLAST 2270.0 Glucose 6-phosphate dehydrogenase, N-terminal domain; Glucose 6-phosphate dehydrogenase
    2 View Details [187..415]
    [432..505]    		 PSI-BLAST 2270.0 Glucose 6-phosphate dehydrogenase, N-terminal domain; Glucose 6-phosphate dehydrogenase

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • glucose-6-phosphate dehydrogenase activity
    		•  5.10379236186634 bayes_pls_golite062009
  • catalytic activity
    		•  1.79741889688267 bayes_pls_golite062009
  • steroid dehydrogenase activity
    		•  1.75109362865449 bayes_pls_golite062009
  • steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  1.55012034958204 bayes_pls_golite062009
  • DNA binding
    		•  1.30649176474402 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.21797427723368 bayes_pls_golite062009
  • retinol dehydrogenase activity
    		•  1.16811519855038 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.16624046427845 bayes_pls_golite062009
  • oxidoreductase activity, acting on CH-OH group of donors
    		•  1.03956654822048 bayes_pls_golite062009
  • binding
    		•  0.982999356179965 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
    		•  0.82673050487418 bayes_pls_golite062009
  • monovalent inorganic cation transmembrane transporter activity
    		•  0.749202992278132 bayes_pls_golite062009
  • alcohol dehydrogenase (NAD) activity
    		•  0.65743456407889 bayes_pls_golite062009
  • transcription factor activity
    		•  0.64823933426147 bayes_pls_golite062009
  • hydrolase activity
    		•  0.64282074902621 bayes_pls_golite062009
  • transcription repressor activity
    		•  0.547377529205729 bayes_pls_golite062009
  • NAD or NADH binding
    		•  0.44922383360529 bayes_pls_golite062009
  • 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
    		•  0.375786741986945 bayes_pls_golite062009
  • 3-alpha(17-beta)-hydroxysteroid dehydrogenase (NAD+) activity
    		•  0.362878028601961 bayes_pls_golite062009
  • coenzyme binding
    		•  0.35922330382799 bayes_pls_golite062009
  • structural molecule activity
    		•  0.34148076461528 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  0.225978107187737 bayes_pls_golite062009
  • kinase activity
    		•  0.201113035937958 bayes_pls_golite062009
  • inorganic cation transmembrane transporter activity
    		•  0.156723490409668 bayes_pls_golite062009
  • glucose binding
    		•  0.13030486887358 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.126337510738706 bayes_pls_golite062009
  • hydrogen ion transmembrane transporter activity
    		•  0.111651152766906 bayes_pls_golite062009
  • protein kinase activity
    		•  0.0808301652371467 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.0244314674300794 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle