Protein Overview: YNL194C

General Information:
Name(s) found:	YNL194C [SGD]
Description(s) found: SHOW ONLY BEST	gi\|732199\|sp\|P40169.1\|YNT4_YEAST RecName: Full=Uncharacterized plasma membrane protein YNL194C [NCBI NR] gi\|6324135\|ref\|NP_014205.1\| Integral membrane protein localized to eisosomes; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS [NCBI NR] gi\|600071\|emb\|CAA55514.1\| N1394 [Saccharomyces cerevisiae] [NCBI NR] pir\|\|S50737 probable membrane protein YNL194c - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|1302189\|emb\|CAA96088.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] Uncharacterized plasma membrane protein YNL194C OS=Saccharomyces cerevisiae GN=YNL194C PE=1 SV=1 [Swiss-Prot] Integral membrane protein localised to eisosomes at the cell periphery associated with endocytosis [mips] Integral membrane protein required for sporulation and plasma membrane sphingolipid content; has sequence similarity to SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS [SGD] Chr XIV from 272706-273611, reverse complement [yeastorf3.fasta] Chr XIV from 273611-272706, reverse complement [yeastorf5.fasta] (P40169) Hypothetical 34.1 kDa protein in WHI3-CHS1 intergenic region [4932.FASTACCERV.txt] YNL194C, Chr XIV from 272706-273611, reverse complement [yeast_orfs2] YNL194C SGDID:S0005138, Chr XIV from 273614-272709, reverse complement, Uncharacterized ORF [yeastflysequest.fasta] Ynl194cp [Saccharomyces cerevisiae]gi\|600071\|emb\|CAA55514.1\| N1394 [Saccharomyces cerevisiae]gi\|1302189\|emb\|CAA96088.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|2132768\|pir\|\|S50737 probable membrane protein YNL194c - yeast (Saccharomyces ce [nrdb_11152004_Chlamydomonas] YNL194C SGDID:S000005138, Chr XIV from 273616-272711, reverse complement, Uncharacterized ORF, "Hypothetical protein" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] YNL194C SGDID:S000005138, Chr XIV from 273616-272711, reverse complement, Verified ORF, "Integral membrane protein localized to eisosomes, large immobile protein structures at the cell cortex associated with endocytosis; sporulation and plasma membrane sp [yeast-contam.fasta] YNL194C SGDID:S000005138, Chr XIV from 273616-272711, reverse complement, Verified ORF, "Integral membrane protein localized to eisosomes; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45; GFP-fusion [SGD_S-cerevisiae_na_08-19-2008_con_reversed.fasta] YNL194C SGDID:S000005138, Chr XIV from 273616-272711, reverse complement, Verified ORF, "Integral membrane protein required for sporulation and plasma membrane sphingolipid content; has sequence similarity to SUR7 and FMP45; GFP-fusion protein is induced [yeast-200209-contam.fasta] N1394 [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Uncharacterized plasma membrane protein YNL194C [nr-271106-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Integral membrane protein localized to eisosomes, large immobile protein structures at the cell cortex associated with endocytosis; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45; Ynl194cp [Sacchar [nr-271106-contam.fasta] YNL194C SGDID:S000005138, Chr XIV from 273616-272711, reverse complement, Verified ORF, "Integral membrane protein required for sporulation and plasma membrane sphingolipid content; has sequence similarity to SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS" [yeast-bovrabprots.fasta] YNL194C SGDID:S000005138, Chr XIV from 273616-272711, reverse complement, Verified ORF, "Integral membrane protein localized to eisosomes, large immobile protein structures at the cell cortex associated with endocytosis; sporulation and plasma membrane sphingolipid content are altered in mutants; has homologs SUR7 and FMP45" [yeast-contam_custom.fasta] [chemostatdb.fasta] Uncharacterized plasma membrane protein YNL194C OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YNL194C PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] YNL194C SGDID:S000005138, Chr XIV from 273615-272710, Genome Release 64-1-1, reverse complement, Verified ORF, "Integral membrane protein required for sporulation and plasma membrane sphingolipid content; has sequence similarity to SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS" [yeast-030211-contam.fasta] YNL194C SGDID:S000005138, Chr XIV from 273615-272710, Genome Release 64-2-1, reverse complement, Verified ORF, "Integral membrane protein; required for sporulation and plasma membrane sphingolipid content; similar to SUR7; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion protein is more abundant at MCCs (membrane compartment occupied by Can1) in the presence of glycerol and oleate; YNL194C has a paralog, FMP45, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
Organism:	Saccharomyces cerevisiae
Length:	301 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA] cell cortex [IDA] integral to membrane [ISS ] endoplasmic reticulum [IDA]
Biological Process:	ascospore formation [IGI][IMP]
Molecular Function:	molecular_function [ND]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSYKKFVYFI NLFFLLGATL LTFFLILAGG RTTGVLKNFY WFQASTSGFN SAPSVTRWYN  60
   61 YNWCGWESRG IAVNCSSKMA AQPFSPRDNF GSSPLMPSTF LNNRNAYYYL SRVGWAMLLI 120
  121 GLFFLLITLV SVIASLIRYN RRTAALATAM SWITLFFITL SACLYTGCYA KAVKAFHHEN 180
  181 RDARLGPKNF GLIWTTVFLL IVNAICCTIM VATHKRNEYI YDRSFASTKT VDSQTPTPVP 240
  241 TNGGIPSSVP VTEVQQSQSH QNHRFFKKLR TKKRTVTSAG DEPDRVQEER VYTEQNVPVV 300
  301 S

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	ASF1	3829 - low filter	Green EM, et al (2005)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

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	BAIT	PREY	HITS	PUBLICATION
View Screen	ROM2	YNL194C	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	YNL194C	Huh WK, et al. (2003)

Protein Structure Data

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Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..301]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2