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Protein Overview: SAM50

General Information:
Name(s) found: SAM50 / YNL026W [SGD]
Description(s) found:
Found 30 descriptions.
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  • Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85 [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 484 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed articleLink to PubMed article]
    mitochondrial outer membrane [IDALink to PubMed articleLink to PubMed article]
    mitochondrial sorting and assembly machinery complex [IDALink to PubMed article]
    Biological Process: protein import into mitochondrial outer membrane [IMPLink to PubMed article]
    protein complex assembly [IMPLink to PubMed articleLink to PubMed article][IPILink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTSSSGVDNE ISLDSPMPIF NESSTLKPIR VAGVVTTGTD HIDPSVLQAY LDDTIMKSIT  60
   61 LGQLVKNADV LNKRLCQHHI ALNAKQSFHF QGNTYISDEK ETHDVVPLME VVSQLDILPP 120
  121 KTFTAKTGTN FGNDNDAEAY LQFEKLIDKK YLKLPTRVNL EILRGTKIHS SFLFNSYSSL 180
  181 SPQSILNLKV FSQFYNWNTN KGLDIGQRGA RLSLRYEPLF LHKLLHNPHS NESPTLFHEW 240
  241 FLETCWRSTK ICSQGTSAPY MYSGTMLSQA GDQLRTILGH TFVLDKRDHI MCPTKGSMLK 300
  301 WSNELSPGKH LKTQLELNSV KSWMNDDFIT FSTTIKTGYL KNLSSQQSLP VHICDKFQSG 360
  361 GPSDIRGFQT FGLGPRDLYD AVGGDAFVSY GLSVFSRLPW KKVEKSNFRL HWFFNGGKLV 420
  421 NHDNTSLGNC IGQLSKEHST STGIGLVLRH PMARFELNFT LPITAHENDL IRKGFQFGLG 480
  481 LAFL

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) SAM35 SAM37 SAM50

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data SAM50 Hazbun TR, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..100] deduced N/A No confident structure predictions are available.
    2 View Details [101..484] MSA 6.121984 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle