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Protein Overview: FUS2

General Information:
Name(s) found: FUS2 / YMR232W [SGD]
Description(s) found:
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  • gi|887613|emb|CAA90203.1| unknown [Saccharomyces cerevisiae] [NCBI NR]
  • gi|6323888|ref|NP_013959.1| Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating; Fus2p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|2498399|sp|Q05670.1|FUS2_YEAST RecName: Full=Nuclear fusion protein FUS2 [NCBI NR]
  • pir||S57599 FUS2 protein - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Nuclear fusion protein FUS2 OS=Saccharomyces cerevisiae GN=FUS2 PE=1 SV=1 [Swiss-Prot]
  • FUS2 Protein required for cell fusion during mating [mips]
  • Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating [SGD]
  • FUS2, Chr XIII from 736925-738958 [yeast_orfs2]
  • Chr XIII from 736925-738958 [yeastorf3.fasta]
  • (Q05670) Nuclear fusion protein FUS2 [4932.FASTACCERV.txt]
  • FUS2 SGDID:S0004845, Chr XIII from 736925-738958, Verified ORF [yeastflysequest.fasta]
  • Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating [Saccharomyces cerevisiae]gi|887613|emb|CAA90203.1| unknown [Saccharomyces cerevisiae]gi|2498399|sp|Q05670|FUS2_YEAST Nucle [nrdb_11152004_Chlamydomonas]
  • FUS2 SGDID:S000004845, Chr XIII from 736925-738958, Verified ORF, "Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Nuclear fusion protein FUS2 [nr-271106-contam.fasta]
  • Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating; Fus2p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • [chemostatdb.fasta]
  • Nuclear fusion protein FUS2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FUS2 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • FUS2 SGDID:S000004845, Chr XIII from 736926-738959, Genome Release 64-1-1, Verified ORF, "Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating" [yeast-030211-contam.fasta]
  • FUS2 SGDID:S000004845, Chr XIII from 736926-738959, Genome Release 64-2-1, Verified ORF, "Cell fusion regulator; cytoplasmic protein localized to shmoo tip; required for alignment of parental nuclei before nuclear fusion during mating; contains a Dbl-homology domain; binds specifically with activated Cdc42p" [20141208_orf_trans.fasta]
  • YMR232W SGDID:S000004845, Chr XIII from 736926-738959, Genome Release 64-1-1, Verified ORF, "Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 677 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    mating projection tip [IDALink to PubMed article]
    Biological Process: regulation of termination of mating projection growth [IMPLink to PubMed article]
    plasma membrane fusion [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFKTSYNLYD LNYPKNDSLT PIRDYKNDYF HKNDDKLPEI VRKPTRKLSK HENKLNDKKF  60
   61 TNKRPASLDL HSIVESLSNK KIYSPINTEI FQNVVRLNLS PQIPNSPHEG CKFYKIVQEF 120
  121 YLSEVEYYNN LLTANNVYRK ALNSDPRFKN KLVKLDSSDE LLLFGNIDTI ASISKILVTA 180
  181 IKDLLLAKQR GKMLDANEWQ KIFTKNEVQQ QLYSTFDISE AFEQHLLRIK STYTSYFVSH 240
  241 QKQMELFTTL RMNKNHFFNK WYEYCLKESG CIKLEDILKS PMKRLTQWID TLETLESCYE 300
  301 DILSPELGLK LSPTRRKYSL FSNKLETEVS EYKSNSMYNF SLTPSEIIQS YDEDQFTHLL 360
  361 KPPDKQNKNI CNASRQESNL DNSRVPSLLS GSSSYYSDVS GLEIVTNTST ASAEMINLKM 420
  421 DEETEFFTLA DHISKFKKVM KGLLELKKNL LKNDLSGIID ISLRRINAWK KVIECERPSG 480
  481 AFFAHDNLIS TMCSSYIDKL HEQKNQVTIL KLTELETDVM NPLERIIAHC TTVKSKLKDL 540
  541 QALKKDYMLF LQEKKANVRD IKRDLLGMHF QNLQNQMKRE LPVFITLIHD TIECILLNYI 600
  601 KVFLKYLEII AGGKKYLQKD LENMSLNDSI ATGQIKNLDI LQCYSKSRYM TKRMVRKDWP 660
  661 FPGDPSGSRV VRKLFEL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen MVP1 FUS2 2 Unpublished Fields Lab Data
    View Screen CLB5 FUS2 2 Unpublished Fields Lab Data
    View Screen UBC6 FUS2 1 Unpublished Fields Lab Data
    View Screen CUS1 FUS2 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data FUS2 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..66] deduced N/A No confident structure predictions are available.
    2 View Details [67..321] PSI-BLAST 40.69897 Dbl's big sister, Dbs
    3 View Details [322..477] PSI-BLAST 40.69897 Dbl's big sister, Dbs
    4 View Details [478..677] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • binding
    		•  2.77939509501739 bayes_pls_golite062009
  • protein binding
    		•  1.73388848066577 bayes_pls_golite062009
  • identical protein binding
    		•  0.30171065418349 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle