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View Structure Prediction Details

Protein: FUS2
Organism: Saccharomyces cerevisiae
Length: 677 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FUS2.

Description E-value Query
Range
Subject
Range
FUS2_YEAST - Nuclear fusion protein FUS2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FUS2 PE=1 SV...
FUS2 - Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before...
0.0 [1..677] [1..677]
gi|15986729 - gi|15986729|gb|AAL11723.1|AF406992_1 A-kinase anchoring protein [Homo sapiens]
0.0 [33..532] [1919..2395]
VAV2_MOUSE - Guanine nucleotide exchange factor VAV2 OS=Mus musculus GN=Vav2 PE=1 SV=1
9.0E-74 [6..454] [86..507]
gi|18476185, gi|... - gi|45383828|ref|NP_989473.1| vav 2 guanine nucleotide exchange factor [Gallus gallus], gi|18476185|g...
5.0E-71 [6..454] [86..507]

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Predicted Domain #1
Region A:
Residues: [1-66]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFKTSYNLYD LNYPKNDSLT PIRDYKNDYF HKNDDKLPEI VRKPTRKLSK HENKLNDKKF  60
   61 TNKRPA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [67-321]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLDLHSIVES LSNKKIYSPI NTEIFQNVVR LNLSPQIPNS PHEGCKFYKI VQEFYLSEVE  60
   61 YYNNLLTANN VYRKALNSDP RFKNKLVKLD SSDELLLFGN IDTIASISKI LVTAIKDLLL 120
  121 AKQRGKMLDA NEWQKIFTKN EVQQQLYSTF DISEAFEQHL LRIKSTYTSY FVSHQKQMEL 180
  181 FTTLRMNKNH FFNKWYEYCL KESGCIKLED ILKSPMKRLT QWIDTLETLE SCYEDILSPE 240
  241 LGLKLSPTRR KYSLF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.69897
Match: 1lb1A_
Description: Dbl's big sister, Dbs
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [322-477]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNKLETEVSE YKSNSMYNFS LTPSEIIQSY DEDQFTHLLK PPDKQNKNIC NASRQESNLD  60
   61 NSRVPSLLSG SSSYYSDVSG LEIVTNTSTA SAEMINLKMD EETEFFTLAD HISKFKKVMK 120
  121 GLLELKKNLL KNDLSGIIDI SLRRINAWKK VIECER

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.69897
Match: 1lb1A_
Description: Dbl's big sister, Dbs
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.77939509501739 bayes_pls_golite062009
protein binding 1.73388848066577 bayes_pls_golite062009
identical protein binding 0.30171065418349 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [478-677]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSGAFFAHDN LISTMCSSYI DKLHEQKNQV TILKLTELET DVMNPLERII AHCTTVKSKL  60
   61 KDLQALKKDY MLFLQEKKAN VRDIKRDLLG MHFQNLQNQM KRELPVFITL IHDTIECILL 120
  121 NYIKVFLKYL EIIAGGKKYL QKDLENMSLN DSIATGQIKN LDILQCYSKS RYMTKRMVRK 180
  181 DWPFPGDPSG SRVVRKLFEL 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle