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View Structure Prediction Details

Protein: FUS2
Organism: Saccharomyces cerevisiae
Length: 677 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for FUS2.

Description E-value Query
Range
Subject
Range
FUS2_YEAST - Nuclear fusion protein FUS2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=FUS2 PE=1 SV...
FUS2 - Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before...
0.0 [1..677] [1..677]
gi|15986729 - gi|15986729|gb|AAL11723.1|AF406992_1 A-kinase anchoring protein [Homo sapiens]
0.0 [33..532] [1919..2395]
VAV2_MOUSE - Guanine nucleotide exchange factor VAV2 OS=Mus musculus GN=Vav2 PE=1 SV=1
9.0E-74 [6..454] [86..507]
gi|18476185, gi|... - gi|45383828|ref|NP_989473.1| vav 2 guanine nucleotide exchange factor [Gallus gallus], gi|18476185|g...
5.0E-71 [6..454] [86..507]

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Predicted Domain #1
Region A:
Residues: [1-66]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFKTSYNLYD LNYPKNDSLT PIRDYKNDYF HKNDDKLPEI VRKPTRKLSK HENKLNDKKF  60
   61 TNKRPA

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.379 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.380 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.360 a.157.1 Skp1 dimerisation domain-like
View Download 0.405 a.23.5 Hemolysin expression modulating protein HHA
View Download 0.405 a.23.5 Hemolysin expression modulating protein HHA
View Download 0.381 g.18.1 Complement control module/SCR domain
View Download 0.380 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.379 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.360 a.157.1 Skp1 dimerisation domain-like
View Download 0.340 a.35.1 lambda repressor-like DNA-binding domains
View Download 0.322 a.144.1 PABC (PABP) domain
View Download 0.319 a.4.1 Homeodomain-like
View Download 0.302 d.58.11 EF-G/eEF-2 domains III and V
View Download 0.299 a.4.6 C-terminal effector domain of the bipartite response regulators
View Download 0.299 a.16.1 S15/NS1 RNA-binding domain
View Download 0.297 d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.291 a.30.2 Homodimeric domain of signal transducing histidine kinase
View Download 0.281 a.2.8 Eukaryotic DNA topoisomerase I, dispensable insert domain
View Download 0.280 b.84.2 Rudiment single hybrid motif
View Download 0.278 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.275 a.108.1 Ribosomal protein L7/12, oligomerisation (N-terminal) domain
View Download 0.274 a.2.7 tRNA-binding arm
View Download 0.263 d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.255 a.3.1 Cytochrome c
View Download 0.244 a.5.2 UBA-like
View Download 0.230 g.18.1 Complement control module/SCR domain
View Download 0.227 a.5.7 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View Download 0.224 a.46.2 Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain
View Download 0.213 d.58.17 Metal-binding domain

Predicted Domain #2
Region A:
Residues: [67-321]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLDLHSIVES LSNKKIYSPI NTEIFQNVVR LNLSPQIPNS PHEGCKFYKI VQEFYLSEVE  60
   61 YYNNLLTANN VYRKALNSDP RFKNKLVKLD SSDELLLFGN IDTIASISKI LVTAIKDLLL 120
  121 AKQRGKMLDA NEWQKIFTKN EVQQQLYSTF DISEAFEQHL LRIKSTYTSY FVSHQKQMEL 180
  181 FTTLRMNKNH FFNKWYEYCL KESGCIKLED ILKSPMKRLT QWIDTLETLE SCYEDILSPE 240
  241 LGLKLSPTRR KYSLF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.69897
Match: 1lb1A_
Description: Dbl's big sister, Dbs
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [322-477]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SNKLETEVSE YKSNSMYNFS LTPSEIIQSY DEDQFTHLLK PPDKQNKNIC NASRQESNLD  60
   61 NSRVPSLLSG SSSYYSDVSG LEIVTNTSTA SAEMINLKMD EETEFFTLAD HISKFKKVMK 120
  121 GLLELKKNLL KNDLSGIIDI SLRRINAWKK VIECER

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.69897
Match: 1lb1A_
Description: Dbl's big sister, Dbs
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.77939509501739 bayes_pls_golite062009
protein binding 1.73388848066577 bayes_pls_golite062009
identical protein binding 0.30171065418349 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [478-677]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PSGAFFAHDN LISTMCSSYI DKLHEQKNQV TILKLTELET DVMNPLERII AHCTTVKSKL  60
   61 KDLQALKKDY MLFLQEKKAN VRDIKRDLLG MHFQNLQNQM KRELPVFITL IHDTIECILL 120
  121 NYIKVFLKYL EIIAGGKKYL QKDLENMSLN DSIATGQIKN LDILQCYSKS RYMTKRMVRK 180
  181 DWPFPGDPSG SRVVRKLFEL 

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


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Created and Maintained by: Michael Riffle