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Protein Overview: EAR1

General Information:
Name(s) found: EAR1 / YMR171C [SGD]
Description(s) found:
Found 25 descriptions.
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  • Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 550 amino acids

    Gene Ontology:
    Cellular Component: endosome [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFKFLIESL LLGSISGQIR CGRSSVIPRG DVSYGGDDTD ELNMDIMLFA FGTLIVVYIV  60
   61 ICIVYFFTKQ IATRLITAYY NEHGPGQRIS LFSDYDENNA HVHSRRLMEN MSLRWPNNLD 120
  121 DADEVRDKLA QLSPEEQFYY KQGEEYIKQN PPFLLNQGLL QQSEDSNPDT TREDPIMNEQ 180
  181 TRQYIQEEGA YAWEFSPNPD MPNHTVIVEN KTEVSFLNYN YDASISTNLP IPCINKVYYC 240
  241 EFKIFETDGP LNSDENVSKG VISFGLSTQP YPYFRLPGRH HHSIAYDSNG ARRFNDSFKL 300
  301 NEQLRTLFPQ CEKGDIVGIG YRSRSGTVFF TRNGKKLNEK SVGGHIRGWK FQYLYPIIGS 360
  361 NVPCQIHVNF GTYGFVYIEA NVKKWGYAKS NGIKLPPPSY EDYGKDTLLE SGGEDNDFDE 420
  421 DFSDGDSDNI AAGSTTNLND DIIIRNGEIL PPPPGFEFTM SPPTGKKIIN EEINLDSLPM 480
  481 LPPSYSDDEH HSKNDKSAIS GRIIGTSRNL ITDEASFDSV DNDNEDENDH ERDPEQFSEF 540
  541 DDYESRMHGI

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run VAM3 Sample: HX12 - trans-SNARE complex formation and fusion are inhibited (control). Hao Xu, et al. (2010)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data EAR1 and SNF7 Huh WK, et al. (2003)
    View Data EAR1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..168] deduced N/A Confident ab initio structure predictions are available.
    2 View Details [169..424] Pfam 26.259637 SPRY domain No confident structure predictions are available.
    3 View Details [425..550] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  1.37879632043452 bayes_pls_golite062009
  • protein binding
    		•  1.15590148654655 bayes_pls_golite062009
  • transporter activity
    		•  0.0373253642688324 bayes_pls_golite062009
  • hydrolase activity
    		•  0.00724990918244621 bayes_pls_golite062009
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle