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View Structure Prediction Details

Protein: EAR1
Organism: Saccharomyces cerevisiae
Length: 550 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EAR1.

Description E-value Query
Range
Subject
Range
EAR1 - Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo protein...
EAR1_YEAST - Protein EAR1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=EAR1 PE=1 SV=1
0.0 [1..550] [1..550]
gi|1526615|emb|C... - ryanodine receptor type 3 [Mustela vison]
gi|1526615 - gi|1526615|emb|CAA69029.1| ryanodine receptor type 3 [Mustela vison]
1.0E-82 [66..378] [922..1213]
gi|2696015 - gi|2696015|dbj|BAA23795.1| brain ryanodine receptor [Homo sapiens]
1.0E-82 [68..378] [931..1214]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
3.0E-82 [66..378] [922..1213]
gi|1212912, gi|4... - gi|46048744|ref|NP_996757.1| ryanodine receptor 3 [Gallus gallus], gi|1212912|emb|CAA64563.1| ryanod...
1.0E-78 [66..378] [921..1212]

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Predicted Domain #1
Region A:
Residues: [1-168]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFKFLIESL LLGSISGQIR CGRSSVIPRG DVSYGGDDTD ELNMDIMLFA FGTLIVVYIV  60
   61 ICIVYFFTKQ IATRLITAYY NEHGPGQRIS LFSDYDENNA HVHSRRLMEN MSLRWPNNLD 120
  121 DADEVRDKLA QLSPEEQFYY KQGEEYIKQN PPFLLNQGLL QQSEDSNP

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.257 0.875 endosome d.19.1 MHC antigen-recognition domain

Predicted Domain #2
Region A:
Residues: [169-424]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DTTREDPIMN EQTRQYIQEE GAYAWEFSPN PDMPNHTVIV ENKTEVSFLN YNYDASISTN  60
   61 LPIPCINKVY YCEFKIFETD GPLNSDENVS KGVISFGLST QPYPYFRLPG RHHHSIAYDS 120
  121 NGARRFNDSF KLNEQLRTLF PQCEKGDIVG IGYRSRSGTV FFTRNGKKLN EKSVGGHIRG 180
  181 WKFQYLYPII GSNVPCQIHV NFGTYGFVYI EANVKKWGYA KSNGIKLPPP SYEDYGKDTL 240
  241 LESGGEDNDF DEDFSD

[Run NCBI BLAST on this sequence.]

Detection Method: Pfam
Confidence: 26.259637
Match: PF00622
Description: SPRY domain

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term Confidence Notes
binding 1.37879632043452 bayes_pls_golite062009
protein binding 1.15590148654655 bayes_pls_golite062009
transporter activity 0.0373253642688324 bayes_pls_golite062009
hydrolase activity 0.00724990918244621 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [425-550]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GDSDNIAAGS TTNLNDDIII RNGEILPPPP GFEFTMSPPT GKKIINEEIN LDSLPMLPPS  60
   61 YSDDEHHSKN DKSAISGRII GTSRNLITDE ASFDSVDNDN EDENDHERDP EQFSEFDDYE 120
  121 SRMHGI

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
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