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Protein Overview: HLJ1

General Information:
Name(s) found: HLJ1 / YMR161W [SGD]
Description(s) found:
Found 30 descriptions.
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  • Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 224 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum membrane [IDALink to PubMed article][ISSLink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: protein folding [ICLink to PubMed article]
    ER-associated protein catabolic process [IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: chaperone regulator activity [ISSLink to PubMed article]
    ATPase activator activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFTEDQEKI ALEILSKDKH EFYEILKVDR KATDSEIKKA YRKLAIKLHP DKNSHPKAGE  60
   61 AFKVINRAFE VLSNEEKRSI YDRIGRDPDD RQMPSRGAAS GFRGSAGGSP MGGGFEDMFF 120
  121 NSRFGGQRAG PPEDIFDFLF NAGGSPFGAS PFGPSASTFS FGGPGGFRVY TNNRGGSPFM 180
  181 RQQPRSRQQQ QQAEENAVNS QLKNMLVLFI IFIVLPMIKD YLFS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) HLJ1 SEC23 SNL1

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SXM1 HLJ1 1 Unpublished Fields Lab Data
    View Screen CPR6 HLJ1 1 Unpublished Fields Lab Data
    View Screen YLR224W HLJ1 1 Unpublished Fields Lab Data
    View Screen UBC7 HLJ1 1 Unpublished Fields Lab Data
    View Screen MSN5 HLJ1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data HLJ1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..148] PSI-BLAST 139.39794 DnaJ chaperone, N-terminal (J) domain
    2 View Details [149..224] PSI-BLAST 8.09691 Cysteine-rich domain of the chaperone protein DnaJ.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.60921541945619 bayes_pls_golite062009
  • protein binding
    		•  0.912937133925792 bayes_pls_golite062009
  • unfolded protein binding
    		•  0.26936882742456 bayes_pls_golite062009
  • heat shock protein binding
    		•  0.162050450070629 bayes_pls_golite062009
  • catalytic activity
    		•  0.106988907594358 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle