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Protein Overview: MDM1

General Information:
Name(s) found: MDM1 / YML104C [SGD]
Description(s) found:
Found 22 descriptions.
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  • Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1127 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [TASLink to PubMed article]
    intermediate filament [TASLink to PubMed article]
    Biological Process: mitochondrion inheritance [IDALink to PubMed article]
    nuclear migration [TASLink to PubMed article]
    mitochondrion organization [TASLink to PubMed article]
    Molecular Function: structural constituent of cytoskeleton [TASLink to PubMed article]
    phosphatidylinositol-3-phosphate binding [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPKFPQFRLI LVLFYLISMI QWSVITFSLG FFLNVCIFAY FVFFKSLPDL PKPQPRFVDI  60
   61 VPESSNTVDV DKELKSVEGL IQDGNAQIGK ELESIVNLII KDFVQPWFTK IDKNSDAEFL 120
  121 KVIKWRLLQT LLVVKDKLMK NDSASLIVLK LLPIFNKHFS TFCDAREAVL SDLTLERHKS 180
  181 ANIDLQIAVE FNKNYKIHKS LSLKPNALQK EIEKSIRKTV IGLLPHLFDN DELDSLLVFT 240
  241 LMTEVLTTCI ISPLIFKFTD PDSWNLRIVS LSQNYFEEKH KVHKIRRMLS KELQDHRKVM 300
  301 NDVANKDVGE PSSEKLELNA EYTGKQFEHY LNQLDSLLDL SDIKYVAYSL ALKIYQLKEN 360
  361 EHLTKENLKY KKRLLLSLNL IESKLSFPGS EIDTASKKLA REANYPDLNM DNGIVLKEMA 420
  421 SFLTSITLKD IVDDSEFLPF FESFLGSVPE TQGSTFLEYS QTIESFKNPL EDATSEDIIS 480
  481 GYSGISTMQL QEISSKFFHN NNLQNMKLLD EGLVKNIILF RNSFQINNDE DTFILARKSV 540
  541 LLLQTEAIKY LDDRFLPLFK KTPSFLKMLS TSHIISTDIY AHFLSRIGGV NNPEQNKIIK 600
  601 DNVKTDFMNP VRIFANPGIT DALDNIVNGS GSKPHKSRIS SNPRYSQLFG SENDNIFKDK 660
  661 LFDDENDNTS EISVVEDQLD HPRNMEKVSV SSGNSGLNPS QFYGSNNFRD NIASLTISID 720
  721 QIEKELELLR HLILKADLTN NQMQLKILKK SQRTLLKELE MKELLKQQYM VQENGNSLFR 780
  781 KTKIYIRSYF SENSSNGLKE ITYYIINIHH FNNGQVSSWD MARRYNEFFE LNTYLKKNFR 840
  841 DLMRQLQDLF PSKVKMSLKY HVTKTLLYEE RKQKLEKYLR ELLSISEICE DNIFRRFLTD 900
  901 PTPFKLNKEY MHDDILEEPL HEPIGSSNST SNSSSVVDLQ SSEDGGELNF YEDERHFFTD 960
  961 SGYPFYSQNK SFVKQICDLF ISLFALNKAN AGWLRGRAII TVLQQLLGST IEKYIKVSIQ1020
 1021 KLRSEDQVFE AIVTFKNMLW GDNGLFERKR NETAEATRSE GERLRTEQLA LTSLQRLFAD1080
 1081 TCGRVVGLRD SHEAAGRVHA MLQNPYLNAS LLLEALDAIL LDIICND

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Qiu et al. (2008) ARP1 JNM1 MDM1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #12 Mitotic Prep1-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #30 Asynchronous Prep6-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen MDM1 ATC1 2 Unpublished Fields Lab Data
    View Screen MDM1 YIR014W 2 Unpublished Fields Lab Data
    View Screen MDM1 SMA1 2 Unpublished Fields Lab Data
    View Screen MDM1 YIR014W 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data MDM1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..80] deduced N/A No confident structure predictions are available.
    2 View Details [81..294] Pfam 97.568636 PXA domain No confident structure predictions are available.
    3 View Details [295..388] deduced N/A Confident ab initio structure predictions are available.
    4 View Details [389..607] ORFEUS 12.29 Regulator of G-protein signalling 4, RGS4
    5 View Details [608..696] deduced N/A Confident ab initio structure predictions are available.
    6 View Details [697..920] PSI-BLAST 22.154902 p40phox NADPH oxidase
    7 View Details [921..1127] MSA 1.075952 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • binding
    		•  1.74066926539061 bayes_pls_golite062009
  • protein binding
    		•  1.46874099847386 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.751540543950607 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.726313915060022 bayes_pls_golite062009
  • enzyme regulator activity
    		•  0.619424511001805 bayes_pls_golite062009
  • enzyme activator activity
    		•  0.423538625413241 bayes_pls_golite062009
  • GTPase activator activity
    		•  0.380332469241193 bayes_pls_golite062009
  • calmodulin binding
    		•  0.144645492942361 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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