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Protein Overview: YRF1-4

General Information:
Name(s) found: YRF1-4 / YLR466W [SGD]
Description(s) found:
Found 22 descriptions.
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  • Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1382 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IC]
    Biological Process: telomere maintenance via recombination [IGILink to PubMed article]
    Molecular Function: DNA helicase activity [IDALink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MWKTLGRVEQ LLPYASLILR NREVLFREPK RGIDEYLEND SFFQMIPVKY REIVLPKLRR  60
   61 DTNKMTAALK NKVAVAIDEL TVPLMWMIHF AVGYPYRYPE LQLLAFAGPQ RNVYVDDTTR 120
  121 RIQLYTDYNK NGSSEPRLKT LDGLTSDYVF YFVTVLRQMQ ICALGNSYDA FNHDPWMDVV 180
  181 GFEDPDQVTN RDISRIVLYS YMFLNTAKGC LVEYATFRQY MRELPKNAPQ KLNFREMRQG 240
  241 LIALGRHCVG SRFETDLYES ATSELMANHS VQTGRNIYGV DSFSLTSVSG TTATLLQERA 300
  301 SERWIQWLGL ESDYHCSFSS TRNAEDVVAG EAASSDHHQK ISRVTRKRPR EPKSTNDILV 360
  361 AGRKLFGSSF EFRDLHQLRL CHEIYMADTP SVAVQAPPGY GKTELFHLPL IALASKGDVK 420
  421 YVSFLFVPYT VLLANCMIRL SRCGCLNVAP VRNFIEEGCD GVTDLYVGIY DDLASTNFTD 480
  481 RIAAWENIVE CTFRTNNVKL GYLIVDEFHN FETEVYRQSQ FGGITNLDFD AFEKAIFLSG 540
  541 TAPEAVADAA LQRIGLTGLA KKSMDINELK RSEDLSRGLS SYPTRMFNLI KEKSEVPLGH 600
  601 VHKIWKKVES QPEEALKLLL ALFEIEPESK AIVVASTTNE VEELACSWRK YFRVVWIHGK 660
  661 LGAAEKVSRT KEFVTDGSMR VLIGTKLVTE GIDIKQLMMV IMLDNRLNII ELIQGVGRLR 720
  721 DGGLCYLLSR KNSWAARNRK GELPPIKEGC ITEQVREFYG LESKKGKKGQ HVGCCGSRTD 780
  781 LSADTVELIE RMDRLAEKQA TASMSIIALP SSFQESNSSD RCRKYCSSDE DSDTCIHGSA 840
  841 NASTNATTNS STNATTTAST NVRTSATTTA SINVRTSAIT TESTNSSTNA TTTASTNVRT 900
  901 SATTTASINV RTSATTTEST NSNTSATTTE STDSNTSATT TESTDSNTSA TTTASTNSST 960
  961 NATTTASTNS STNATTTEST NASAKEDANK DGNAEDNRFH PVTDINKESY KRKGSQMVLL1020
 1021 ERKKLKAQFP NTSENMNVLQ FLGFRSDEIK HLFLYGIDVY FCPEGVFTQY GLCKGCQKMF1080
 1081 ELCVCWAGQK VSYRRMAWEA LAVERMLRND EEYKEYLEDI EPYHGDPVGY LKYFSVKRGE1140
 1141 IYSQIQRNYA WYLAITRRRE TISVLDSTRG KQGSQVFRMS GRQIKELYYK VWSNLRESKT1200
 1201 EVLQYFLNWD EKKCREEWEA KDDTVFVEAL EKVGVFQRLR SMTSAGLQGP QYVKLQFSRH1260
 1261 HRQLRSRYEL SLGMHLRDQL ALGVTPSKVP HWTAFLSMLI GLFYNKTFRQ KLEYLLEQIS1320
 1321 EVWLLPHWLD LANVEVLAAD NTRVPLYMLM VAVHKELDSD DVPDGRFDII LLCRDSSREV1380
 1381 GE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RLF2 phosphorylation data - cascade search Green EM, et al (2005)
    View Run MLP2 #24 Asynchronous Prep3-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..93] MSA 1.006962 View MSA. No confident structure predictions are available.
    2 View Details [94..173] deduced N/A No confident structure predictions are available.
    3 View Details [174..314] MSA 1.255996 View MSA. No confident structure predictions are available.
    4 View Details [315..778] PSI-BLAST 168.0 Initiation factor 4a
    5 View Details [779..1007] MSA 76.388997 View MSA. No confident structure predictions are available.
    6 View Details [1008..1382] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • binding
    		•  0.36550713198424 bayes_pls_golite062009
  • catalytic activity
    		•  0.234613562021476 bayes_pls_golite062009
  • nucleoside-triphosphatase activity
    		•  0.166100211611062 bayes_pls_golite062009
  • pyrophosphatase activity
    		•  0.159702441149605 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides
    		•  0.149170905385965 bayes_pls_golite062009
  • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
    		•  0.147838751017739 bayes_pls_golite062009
  • hydrolase activity
    		•  0.0436758932827116 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.77

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle