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Protein Overview: DUS3

General Information:
Name(s) found: DUS3 / YLR401C [SGD]
Description(s) found:
Found 16 descriptions.
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  • Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 609 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDALink to PubMed article]
    cytoplasm [IDALink to PubMed article]
    Biological Process: ribosome biogenesis [RCALink to PubMed article]
    tRNA modification [ISSLink to PubMed article]
    Molecular Function: tRNA dihydrouridine synthase activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEQNAEKRSI VGDDNSTVKR QDTSPSKGIA HIKPEYIVPL KQNENQKVAI YDEEMSSDRM  60
   61 TNEFAGGTNK KNKNGRGKKR GQNKNRDNRQ VKEQNVLCPR LIHGDISKCS FGDNCRFVHD 120
  121 INLYLSTKKP EVESNIFPSC PVFNSLGFCP MGFKCRFLSS HLNKEDNILI SKKEIDPDAQ 180
  181 TIWSVKGEVN HISPERKLDL IKRRFPFTKS NEILEIIDSF QQECRDSMKP EEEVESTPQL 240
  241 KKQDPDVEQP VAPQVEQRNK ELSEHRMKQR EVYLKYKDTR YFAQEKKPLD LYHKKIVSPL 300
  301 TTVGNLPYRR LMRKLGADVT YSEMALAVPL IQGTNSEWAL PKAHTSEFPG FGVQVACSKA 360
  361 WQAAKAAEAL ANSVSEISEI NLNSGCPIDL LYRQGSGSAL LDNPARMIRC LNAMNYVSKD 420
  421 IPITVKIRTG TKEGHPIAEG LVKRLVNETD VAAITLHGRS RQQRYTKSAD WDYVSQVADT 480
  481 LRSAEADFIE TEQGKEGRDS KNRIQFVGNG DVNNFEDWYR YLNGNENIDS VMVARGALIK 540
  541 PWIFEEVESQ QYLDKTSTER LDILRDYAQF SMEHWGTDEY GISQCRRFFC EFMSFFHRYV 600
  601 PWVFVKDTL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..257] MSA 24.153996 View MSA. No confident structure predictions are available.
    2 View Details [258..609] PSI-BLAST 51.39794 Dihydroorotate dehydrogenase
    3 View Details [180..276] deduced N/A No confident structure predictions are available.
    4 View Details [277..609] PSI-BLAST 64.221849 Crystal structure of a putative flavin oxidoreductase with flavin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • nucleic acid binding
    		•  2.13899087582327 bayes_pls_golite062009
  • catalytic activity
    		•  1.94749091175302 bayes_pls_golite062009
  • tRNA dihydrouridine synthase activity
    		•  1.94490879164338 bayes_pls_golite062009
  • binding
    		•  1.2785695107981 bayes_pls_golite062009


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle