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View Structure Prediction Details

Protein: DUS3
Organism: Saccharomyces cerevisiae
Length: 609 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DUS3.

Description E-value Query
Range
Subject
Range
DUS3 - Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p,...
0.0 [1..609] [1..609]
gi|14249957 - gi|14249957|gb|AAH08362.1| DUS3L protein [Homo sapiens]
0.0 [38..601] [28..550]
DUS3L_MOUSE - tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like OS=Mus musculus GN=Dus3l PE=1 SV=1
0.0 [39..601] [57..574]
DUS3_SCHPO - tRNA-dihydrouridine(47) synthase [NAD(P)(+)] OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) ...
dus3 - tRNA dihydrouridine synthase Dus3
4.0E-97 [62..601] [12..550]
DUS3L_ARATH - tRNA-dihydrouridine synthase 3-like OS=Arabidopsis thaliana GN=At4g38890 PE=2 SV=1
1.0E-95 [1..601] [5..632]
CG10463-PA - This gene is referred to in FlyBase by the symbol Dmel\CG10463 (CG10463, FBgn0032819). It is a prote...
1.0E-93 [26..601] [2..542]
CE19615 - status:Confirmed UniProt:Q9TYN2 protein_id:AAD12825.1
9.0E-83 [24..601] [8..492]
gi|12721426, gi|... - gi|15602952|ref|NP_246024.1| hypothetical protein PM1087 [Pasteurella multocida subsp. multocida str...
7.0E-80 [282..607] [1..303]

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Predicted Domain #1
Region A:
Residues: [1-257]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEQNAEKRSI VGDDNSTVKR QDTSPSKGIA HIKPEYIVPL KQNENQKVAI YDEEMSSDRM  60
   61 TNEFAGGTNK KNKNGRGKKR GQNKNRDNRQ VKEQNVLCPR LIHGDISKCS FGDNCRFVHD 120
  121 INLYLSTKKP EVESNIFPSC PVFNSLGFCP MGFKCRFLSS HLNKEDNILI SKKEIDPDAQ 180
  181 TIWSVKGEVN HISPERKLDL IKRRFPFTKS NEILEIIDSF QQECRDSMKP EEEVESTPQL 240
  241 KKQDPDVEQP VAPQVEQ

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [258-609]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RNKELSEHRM KQREVYLKYK DTRYFAQEKK PLDLYHKKIV SPLTTVGNLP YRRLMRKLGA  60
   61 DVTYSEMALA VPLIQGTNSE WALPKAHTSE FPGFGVQVAC SKAWQAAKAA EALANSVSEI 120
  121 SEINLNSGCP IDLLYRQGSG SALLDNPARM IRCLNAMNYV SKDIPITVKI RTGTKEGHPI 180
  181 AEGLVKRLVN ETDVAAITLH GRSRQQRYTK SADWDYVSQV ADTLRSAEAD FIETEQGKEG 240
  241 RDSKNRIQFV GNGDVNNFED WYRYLNGNEN IDSVMVARGA LIKPWIFEEV ESQQYLDKTS 300
  301 TERLDILRDY AQFSMEHWGT DEYGISQCRR FFCEFMSFFH RYVPWVFVKD TL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 51.39794
Match: 1ep1A_
Description: Dihydroorotate dehydrogenase
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [180-276]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QTIWSVKGEV NHISPERKLD LIKRRFPFTK SNEILEIIDS FQQECRDSMK PEEEVESTPQ  60
   61 LKKQDPDVEQ PVAPQVEQRN KELSEHRMKQ REVYLKY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [277-609]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KDTRYFAQEK KPLDLYHKKI VSPLTTVGNL PYRRLMRKLG ADVTYSEMAL AVPLIQGTNS  60
   61 EWALPKAHTS EFPGFGVQVA CSKAWQAAKA AEALANSVSE ISEINLNSGC PIDLLYRQGS 120
  121 GSALLDNPAR MIRCLNAMNY VSKDIPITVK IRTGTKEGHP IAEGLVKRLV NETDVAAITL 180
  181 HGRSRQQRYT KSADWDYVSQ VADTLRSAEA DFIETEQGKE GRDSKNRIQF VGNGDVNNFE 240
  241 DWYRYLNGNE NIDSVMVARG ALIKPWIFEE VESQQYLDKT STERLDILRD YAQFSMEHWG 300
  301 TDEYGISQCR RFFCEFMSFF HRYVPWVFVK DTL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 64.221849
Match: 1vhnA
Description: Crystal structure of a putative flavin oxidoreductase with flavin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
nucleic acid binding 2.13899087582327 bayes_pls_golite062009
catalytic activity 1.94749091175302 bayes_pls_golite062009
tRNA dihydrouridine synthase activity 1.94490879164338 bayes_pls_golite062009
binding 1.2785695107981 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle