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Protein Overview: VPS38

General Information:
Name(s) found: VPS38 / YLR360W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 439 amino acids

    Gene Ontology:
    Cellular Component: cellular_component [ND]
    Biological Process: late endosome to vacuole transport [IGILink to PubMed article][IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKRFLLSRRQ RHLRMICFHN ISLFRANGDS KLIKEYGDGF IPCFFILESI RGELLYVSEV  60
   61 QSGSLRKLSF QELPKLTGAS TMIVLKLVGL VPSDILCTIS SDKNGIIDDK WCVLCTYTID 120
  121 LNKLQPINED TVLITGTNAP VLDLIDGSYT LAAEKIKPLK GLVSSHKRNI SQVKIKFSLA 180
  181 YSSLLKLNKL LEYSSQVHEE INEISSKIED DFLSLKNQNH WYMRTVQKSI ETLEKEVLQR 240
  241 KKSKKNIEMA QLESNDTINH SKTELSLMSQ DESINDDYGS IYSRFVQIKD RLDQLRFKKL 300
  301 YQLIGIFHST DLFNSDRGYI YFEKPSSVND VINRLKLKPL NIEILLRQAG ESTKHREYVN 360
  361 SQLGYYLLFL HLTAIQIFKA PLPYRLMYYG STSVIDSQYP LYFTDQMISK HQAKLIKAIH 420
  421 YFNADILQFK QILENYRPT

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Gavin AC, et al. (2006) VPS15 VPS30 VPS34 VPS38

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MIH1 control 1 McCusker D, et al (2007)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data VPS38 Huh WK, et al. (2003)
    View Data VPS38 and SNF7 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..128] deduced N/A No confident structure predictions are available.
    2 View Details [129..314] PSI-BLAST 2.69897 Heavy meromyosin subfragment
    3 View Details [315..439] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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