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Protein Overview: ARV1

General Information:
Name(s) found: ARV1 / YLR242C [SGD]
Description(s) found:
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  • gi|74644964|sp|Q06541.1|ARV1_YEAST RecName: Full=Protein ARV1 [NCBI NR]
  • gi|662341|gb|AAB67397.1| Arv1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|6323271|ref|NP_013343.1| Protein required for normal intracellular sterol distribution and for sphingolipid metabolism; similar to Nup120p and C. elegans R05H5.5 protein; Arv1p [Saccharomyces cerevisiae] [NCBI NR]
  • gi|51013143|gb|AAT92865.1| YLR242C [Saccharomyces cerevisiae] [NCBI NR]
  • pir||S59388 probable membrane protein YLR242c - yeast (Saccharomyces cerevisiae) [NCBI NR]
  • Protein ARV1 OS=Saccharomyces cerevisiae GN=ARV1 PE=1 SV=1 [Swiss-Prot]
  • ARV1 Protein involved in sterol uptake and distribution into the plasma membrane [mips]
  • Protein functioning in transport of glycosylphosphatidylinositol intermediates into the ER lumen; required for normal intracellular sterol distribution and for sphingolipid metabolism; similar to Nup120p and C. elegans R05H5.5 protein [SGD]
  • ARV1, Chr XII from 622918-623883, reverse complement [yeast_orfs2]
  • Chr XII from 622918-623883, reverse complement [yeastorf3.fasta]
  • Chr XII from 623883-622918, reverse complement [yeastorf5.fasta]
  • >Q06541 (Q06541) Chromosome XII COSMID 9672 [4932.FASTACCERV.txt]
  • ARV1 SGDID:S0004232, Chr XII from 623885-622920, reverse complement, Verified ORF [yeastflysequest.fasta]
  • Arv1p [Saccharomyces cerevisiae]gi|51013143|gb|AAT92865.1| YLR242C [Saccharomyces cerevisiae]gi|1363735|pir||S59388 probable membrane protein YLR242c - yeast (Saccharomyces cerevisiae)gi|662341|gb|AAB67397.1| Arv1p [Saccharomyces cerevisiae] [nrdb_11152004_Chlamydomonas]
  • (Q06541) Arv1p (YLR242C) [cerv4932.FASTAC]
  • ARV1 SGDID:S000004232, Chr XII from 623885-622920, reverse complement, Verified ORF, "Protein required for normal intracellular sterol distribution and for sphingolipid metabolism; similar to Nup120p and C. elegans R05H5.5 protein" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta]
  • ARV1 SGDID:S000004232, Chr XII from 623885-622920, reverse complement, Verified ORF, "Protein functioning in transport of glycosylphosphatidylinositol intermediates into the ER lumen; required for normal intracellular sterol distribution and for sphingoli [yeast-200209-contam.fasta]
  • Arv1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • YLR242C [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • Protein ARV1 [nr-271106-contam.fasta]
  • Protein required for normal intracellular sterol distribution and for sphingolipid metabolism; similar to Nup120p and C. elegans R05H5.5 protein; Arv1p [Saccharomyces cerevisiae] [nr-271106-contam.fasta]
  • ARV1 SGDID:S000004232, Chr XII from 623885-622920, reverse complement, Verified ORF, "Protein functioning in transport of glycosylphosphatidylinositol intermediates into the ER lumen; required for normal intracellular sterol distribution and for sphingolipid metabolism; similar to Nup120p and C. elegans R05H5.5 protein" [yeast-bovrabprots.fasta]
  • [chemostatdb.fasta]
  • Protein ARV1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ARV1 PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta]
  • ARV1 SGDID:S000004232, Chr XII from 623883-622918, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein functioning in transport of glycosylphosphatidylinositol intermediates into ER lumen; required for normal intracellular sterol distribution; human ARV1 required for normal cholesterol and bile acid homeostasis; similar to Nup120p" [yeast-030211-contam.fasta]
  • ARV1 SGDID:S000004232, Chr XII from 623883-622918, Genome Release 64-2-1, reverse complement, Verified ORF, "Cortical ER protein; implicated in the membrane insertion of tail-anchored C-terminal single transmembrane domain proteins; may function in transport of glycosylphosphatidylinositol intermediates into ER lumen; required for normal intracellular sterol distribution; human ARV1 required for normal cholesterol and bile acid homeostasis; similar to Nup120p" [20141208_orf_trans.fasta]
  • TR8369|c0_g1_i1|g.5796 ORF TR8369|c0_g1_i1|g.5796 TR8369|c0_g1_i1|m.5796 type:complete len:322 (+) TR8369|c0_g1_i1:83-1048(+) [Y12_S_cerevisiae-Sep2015-contam.fasta]
  • TR4031|c0_g1_i1|g.2726 ORF TR4031|c0_g1_i1|g.2726 TR4031|c0_g1_i1|m.2726 type:complete len:322 (+) TR4031|c0_g1_i1:93-1058(+) [DBVPG6044_S_cerevisiae-Sep2015-contam.fasta]
  • YLR242C SGDID:S000004232, Chr XII from 623883-622918, Genome Release 64-1-1, reverse complement, Verified ORF, "Protein functioning in transport of glycosylphosphatidylinositol intermediates into ER lumen; required for normal intracellular sterol distribution; human ARV1 required for normal cholesterol and bile acid homeostasis; similar to Nup120p" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
  • ID=asmbl_7144|g.4537 ORF ID=asmbl_7144|g.4537 ID=asmbl_7144|m.4537 type:complete len:322 (+) ID=asmbl_7144:271-1236(+) [DBVPG6044_quiverGenomes_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
  • ID=asmbl_7430|g.4598 ORF ID=asmbl_7430|g.4598 ID=asmbl_7430|m.4598 type:complete len:322 (+) ID=asmbl_7430:81-1046(+) [Y12_quiver_Trinity_v2_2_0_PASA_2June2016-contam.fasta]
  • Protein ARV1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ARV1 PE=2 SV=1 [Swanson-Carlisle-Scereplusabalone-contam.fasta]
    • Organism: Saccharomyces cerevisiae
    Length: 321 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [ISSLink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed article]
    Golgi apparatus [IDALink to PubMed article]
    Biological Process: sterol transport [IMPLink to PubMed article]
    telomere maintenance [IMPLink to PubMed article]
    sterol metabolic process [ISSLink to PubMed article]
    sphingolipid metabolic process [IMPLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MICITCMRPV DSLYTVYSND HIQLTDCPYC QETVDKYVEI DNVLLFIDLL LLKAGAYRHL  60
   61 VFNALELHLS KYPKRKALND CQCLRDYTQA LLFNVKNWFC KYDRLNRLWL LLLSFEIYLT 120
  121 WVTEESKYIY YLNRNNNDGK LIMLSKKLPE SFKWDSAIMR NTITSKVFTW SPPIQYLYFA 180
  181 SYCILDVSLF HTFTQYFILK KLHWKHYSVS SKDVISYTIL LSYGAKIFPI LMLIWPYDTL 240
  241 ISMSIIKWVA NLYIIESLKI VTNLSYWNII KIFISVSLLR YFMVKPILIV FVAKFNFSVI 300
  301 KNLIHQEFIL LLQKSGTYLL L

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen SXM1 ARV1 1 Unpublished Fields Lab Data
    View Screen RAD6 ARV1 1 Unpublished Fields Lab Data
    View Screen RRB1 ARV1 1 Unpublished Fields Lab Data
    View Screen YIF1 ARV1 1 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..135] MSA 5.009983 View MSA. Confident ab initio structure predictions are available.
    2 View Details [136..321] deduced N/A Confident ab initio structure predictions are available.
    3 View Details [162..321] deduced N/A No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.84624717401156 bayes_pls_golite062009
  • protein binding
    		•  1.70162902007087 bayes_pls_golite062009
  • transporter activity
    		•  1.30067041733468 bayes_pls_golite062009
  • receptor activity
    		•  1.27081218639227 bayes_pls_golite062009
  • transcription regulator activity
    		•  1.1514442454341 bayes_pls_golite062009
  • nucleic acid binding
    		•  1.15037818154029 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.07971596062462 bayes_pls_golite062009
  • DNA binding
    		•  1.07906220177233 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  0.809838091223165 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.555014154605011 bayes_pls_golite062009
  • transcription factor activity
    		•  0.4825638884734 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.253562998805943 bayes_pls_golite062009
  • signal transducer activity
    		•  0.212488443103452 bayes_pls_golite062009
  • molecular transducer activity
    		•  0.212488443103452 bayes_pls_golite062009
  • catalytic activity
    		•  0.133319360419662 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.0849070471490733 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle