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Protein Overview: IZH3

General Information:
Name(s) found: IZH3 / YLR023C [SGD]
Description(s) found:
Found 27 descriptions.
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  • Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 543 amino acids

    Gene Ontology:
    Cellular Component: membrane [ISSLink to PubMed article][TASLink to PubMed article]
    endoplasmic reticulum [IDALink to PubMed article]
    Biological Process: lipid metabolic process [TASLink to PubMed article]
    cellular zinc ion homeostasis [IMPLink to PubMed article][ISSLink to PubMed article]
    Molecular Function: metal ion binding [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMDSSSKSLT QYIPSPMGSL SRLKQKGVDN FQKVKKSGKS IYNYNYSKFV PHPFSTIDES  60
   61 VKHSESGRYD DLEIIRPTKE KEVTSSVYKR NSGKSLNTES QFSLGDSDAA TLVNSVATFK 120
  121 LNNASTSTSL VSSSSTVCSQ AKSSLRSPTS RLNDTKIKEE NNYISSVKDY CGPMRKSMVK 180
  181 TEILIEEPLN PTTDIKSFIN SYNHGKAYSL GETQHLHYYQ LPFPWRENRY IIHGYRFYNT 240
  241 HSKSLLSIFN WYGWHNETSN IWSHLLGAIY IIYLAIYDFP QSEVWRNSQV PPQARWIVFM 300
  301 FLAAALKCML SSVFWHTFNG TSFLKLRSKF ACVDYSGITI LITASILTTE FVTMYSCYWA 360
  361 MYTYMSISLA LGVFGVFMNW SPRFDRPEAR PLRIRFFILL ATMGVLSFLH LIFLTDLHYA 420
  421 ATLFSPVTYK SVVWYLVGVV FYGSFIPERF RSDVQVDKTI PTNYELSTDL EIITKQREIH 480
  481 FREVPTAHSK CSSCPSHAKS FKSLWWVDYF GCSHTFWHFF VVLGVIGHYR AILDMFAKRW 540
  541 ILS

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Krogan NJ, et al. (2006) ARB1 BUD9 FAL1 IZH3 TIF1, TIF2 YDR239C

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #32 Asynchronous Prep-No Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data IZH3 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..174] deduced N/A No confident structure predictions are available.
    2 View Details [175..543] Pfam 117.113509 Haemolysin-III related No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle