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Protein Overview: MEU1

General Information:
Name(s) found: MEU1 / YLR017W [SGD]
Description(s) found:
Found 26 descriptions.
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  • Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 337 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IDALink to PubMed article]
    Biological Process: glutamate biosynthetic process [IMPLink to PubMed article]
    L-methionine salvage from methylthioadenosine [IDALink to PubMed article][IMPLink to PubMed article]
    Molecular Function: S-methyl-5-thioadenosine phosphorylase activity [IDALink to PubMed article][IMPLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRIKNTFSV AKRLKLSKVM TNSELPSIFE GTVDLGIIGG TGLYNLDCLE PIALLPPMVT  60
   61 PWGTTSSPVT ISQFVGTNSH FHVAFIARHG INHEYPPTKV PFRANMAALK NLNCKAVLSF 120
  121 SAVGSLQPHI KPRDFVLPQQ IIDRTKGIRH SSYFNDEGLV GHVGFGQPFS QKFAEYIYQF 180
  181 KNEITNPESE EPCHLHYDKD MTVVCMEGPQ FSTRAESKMY RMFGGHVINM SVIPEAKLAR 240
  241 ECELPYQMIC MSTDYDAWRD EAEPVTVETV IGNLTNNGRN ANILASKIIV SMAKEIPEFM 300
  301 HTGDGLRGSI KKSISTKPEA MSKETLERLR YLFPNYW

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data MEU1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..337] PSI-BLAST 438.491979 5'-deoxy-5'-methylthioadenosine phosphorylase


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle