Protein Overview: YKR078W

General Information:
Name(s) found:	YKR078W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6322931\|ref\|NP_013004.1\| Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P); Ykr078wp [Saccharomyces ce [NCBI NR] gi\|549636\|sp\|P36158.1\|YK58_YEAST RecName: Full=Uncharacterized protein YKR078W [NCBI NR] pir\|\|S38155 hypothetical protein YKR078w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|486555\|emb\|CAA82157.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] Uncharacterized protein YKR078W OS=Saccharomyces cerevisiae GN=YKR078W PE=1 SV=1 [Swiss-Prot] Protein of unknown function localised to cytoplasm [mips] Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) [SGD] YKR078W, Chr XI from 584588-586345 [yeast_orfs2] Chr XI from 584588-586345 [yeastorf3.fasta] (P36158) Hypothetical 68.3 kDa protein in SIS2-MTD1 intergenic region [4932.FASTACCERV.txt] YKR078W SGDID:S0001786, Chr XI from 584594-586351, Uncharacterized ORF [yeastflysequest.fasta] Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate [Saccharomyces cerevisiae]gi\|486555\|emb\|CAA82157.1\| unnamed protein product [Saccharomyces cerevisiae]gi\|539277\|pir\|\|S38155 hypothetical protein YKR078w - yeast [nrdb_11152004_Chlamydomonas] YKR078W SGDID:S000001786, Chr XI from 584594-586351, Uncharacterized ORF, "Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] YKR078W SGDID:S000001786, Chr XI from 584594-586351, Verified ORF, "Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate [yeast-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Hypothetical 68.3 kDa protein in SIS2-MTD1 intergenic region [nr-271106-contam.fasta] Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P); Ykr078wp [Saccharomyces cerevisiae] [nr-271106-contam.fasta] YKR078W SGDID:S000001786, Chr XI from 584594-586351, Verified ORF, "Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)" [yeast-bovrabprots.fasta] [chemostatdb.fasta] Uncharacterized protein YKR078W OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YKR078W PE=1 SV=1 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] YKR078W SGDID:S000001786, Chr XI from 584952-586709, Genome Release 64-1-1, Verified ORF, "Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P)" [yeast-030211-contam.fasta] YKR078W SGDID:S000001786, Chr XI from 584952-586709, Genome Release 64-2-1, Verified ORF, "Cytoplasmic protein of unknown function; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P); YKR078W has a paralog, VPS5, that arose from the whole genome duplication" [20141208_orf_trans.fasta]
Organism:	Saccharomyces cerevisiae
Length:	585 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA]
Biological Process:	protein transport [ISS]
Molecular Function:	protein transporter activity [ISS] phosphatidylinositol-3-phosphate binding [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MENDKASHAS PSIGVNEFVV QGEISIDDSE RSVKSVSVSI SDDEDSKTDV QDNMATPSTR  60
   61 SKFQTDLAID NRLLEKDPKY KKLFTEKRRR RRPESCINLM TKGKGTGQKD NINDQIFSLR 120
  121 ILPGSDLNSL KDSLWIIKIS TQPDVEKTIA RAFSDFYWLY HQLQNNHWGK TIPPPTRSNI 180
  181 LVEKDEFAIN HLFMIRNNEK YDPIFNFKPE YIISLQLMAM IKHIFNDKVL RLDSNFIDFI 240
  241 SWDDDLPESL QIVVDDSTFT GDKILMTSSQ FRELKEFHKQ SKKVESITNS HASLIPVTEL 300
  301 TEIYISPTKL FSRKDYQRLF QPQSTDNTFN NNDPLIQEWI PKSKTLFTSL SFGSSAPTYQ 360
  361 EASTEIQACH DWVSISKEQW KQLLYHVLQY IVDEAVKVNS VINEFTECLK QISLDEVIRA 420
  421 NSELFLKFSK LNESFLKKFK GASRQDILKL IILFDENVRF CESFESILNQ RLKLGKILSI 480
  481 IEVDLDKKKN FLDKLSPGNN NSNNEDLKIR TAEDEYRIVL KRYNRVKQSW EKIMEDILNE 540
  541 RKEFEKREAA EVNSCLKSIR DLNMDEKKHY LQLWQDFVPD EHISQ

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Krogan NJ, et al. (2006)		AIM18 PLM2 SPO75 YKR078W

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	RPA135	No Comments	Schneider, DA, et al. (2006)
View Run	MLP2	#03 Alpha Factor Prep1-TiO2 Flowthrough	Keck JM, et al. (2011)

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	YKR078W	RFC2	2	Unpublished Fields Lab Data

Microscopy / Localization Data

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	PROTEIN(S)	PUBLICATION
View Data	YKR078W	Huh WK, et al. (2003)

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..253]	ab initio	9.92	No description for 1h6hA was found.
2	View Details	[254..355]	MSA	1.058993	View MSA. No confident structure predictions are available.
3	View Details	[356..585]	ab initio	8.82	No description for 1i84S was found.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Source: Reynolds et al. (2008)

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2