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Protein Overview: YKL222C

General Information:
Name(s) found: YKL222C [SGD]
Description(s) found:
Found 29 descriptions.
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  • Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 705 amino acids

    Gene Ontology:
    Cellular Component: ribosome [IDALink to PubMed article]
    Biological Process: biological_process [ND]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKNTELSQKK KLDRQSRRKP AKSCHFCRVR KLKCDRVRPF CGSCSSRNRK QCEYKENTSA  60
   61 MEDQLRKKYR RCSKLEMARR IEELESQLTK QSQPNIHEGQ NPLSNMRYLS SKHNRHILYG 120
  121 PTSYRAILAT QTDTFAKYRE EIWQVLKLSR NNWKREHHYS TLSEISSIET APPHSGSPSV 180
  181 IEYLCESLPN YEVLCEYLTD FFASDFYDSY QIVHKEKVLR DLQDCFVKGP RSHKTGQHTI 240
  241 ISLNLDSKKN YYKVGVMTAI MCLASHPKEV PEAIEVFHKV LTSFVSAKVF YTERVQFLFL 300
  301 RYLYINVAGL DGGDQSHCIF IHGLTIDTAI HMGLNEDLRR LYLSKNHPIE EIPYLERLWL 360
  361 WILFTDVKIS LSTGIPVRIN DDFVNKVRLE NYSSSGDILL YKTTLRLRNI MKQIHAREKP 420
  421 PDIPLIIEDL KKFTIKMFKP LDFYLNASNL NGNEFTELQL WHATLHMIGS LSNLYTLTHQ 480
  481 DFDARIFNFS VLAPLNSLHL CFNVLETYFE LDNSKLSSKS LCLSKKWPHL NNALFLIYVN 540
  541 AFRALIQIYT IFLQYMENKD IQLFIQRNSS ALTYSICPGD FEGPHNKCIS LKIAFKEMEN 600
  601 IFDHIHQEKL KPLTQIWQNS YYFSIIISME KIGRRAFNKG MKNIDEGPET ENDATENSLT 660
  661 TILNDLEGPL EDFSENFIDD ILGSPSAFFD TAISGWSNFE DFFSR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #19 Asynchronous Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)
    View Run MLP2 #19b Asynchronous Prep1-new search criteria Keck JM, et al. (2011)
    View Run MLP2 #19a Asynchronous Prep1-new search criteria Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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      PROTEIN(S) PUBLICATION
    View Data YKL222C Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..95] PSI-BLAST 54.94696 Hap1 (Cyp1); HAP1
    2 View Details [96..208] deduced N/A No confident structure predictions are available.
    3 View Details [209..452] MSA 3.100987 View MSA. No confident structure predictions are available.
    4 View Details [453..518] deduced N/A No confident structure predictions are available.
    5 View Details [519..705] MSA 1.010967 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  4.56444258780502 bayes_pls_golite062009
  • DNA binding
    		•  4.26146437716972 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.17369933547911 bayes_pls_golite062009
  • transcription factor activity
    		•  3.049435548132 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.98081393153291 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.93914501897006 bayes_pls_golite062009
  • binding
    		•  2.91929847152301 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  2.44382866473054 bayes_pls_golite062009
  • transcription activator activity
    		•  2.24483536326713 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.90

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle