Protein Overview: ZRT3

General Information:
Name(s) found:	ZRT3 / YKL175W [SGD]
Description(s) found: SHOW ONLY BEST	gi\|6322673\|ref\|NP_012746.1\| Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency; Zrt3p [Saccharomyces cerevisiae] [NCBI NR] gi\|549739\|sp\|P34240.2\|ZRT3_YEAST RecName: Full=Zinc-regulated transporter 3; AltName: Full=Vacuolar membrane zinc transporter [NCBI NR] pir\|\|S38005 hypothetical protein YKL175w - yeast (Saccharomyces cerevisiae) [NCBI NR] gi\|486308\|emb\|CAA82017.1\| unnamed protein product [Saccharomyces cerevisiae] [NCBI NR] gi\|407506\|emb\|CAA81511.1\| unknown [Saccharomyces cerevisiae] [NCBI NR] gi\|1582528\|prf\|\|2118403B ORF [NCBI NR] Zinc-regulated transporter 3 OS=Saccharomyces cerevisiae GN=ZRT3 PE=1 SV=2 [Swiss-Prot] Uncharacterized protein YKL175W - Saccharomyces cerevisiae (Baker's yeast) [Swiss-Prot] ZRT3 Vacuolar zinc efflux protein [mips] Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency [SGD] ZRT3, Chr XI from 118795-120306 [yeast_orfs2] Chr XI from 118795-120306 [yeastorf3.fasta] Chr XI from 118794-120305 [yeastorf4.fasta] (P34240) Hypothetical 55.4 kDa protein in STE3-GIN10 intergenic region [4932.FASTACCERV.txt] ZRT3 SGDID:S0001658, Chr XI from 118798-120309, Verified ORF [yeastflysequest.fasta] Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency [Saccharomyces cerevisiae]gi\|407506\|emb\|CAA81511.1\| unknown [Saccharomyces cerevisi [nrdb_11152004_Chlamydomonas] ZRT3 SGDID:S000001658, Chr XI from 118798-120309, Verified ORF, "Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency" [SGD_S-cerevisiae_na_12-16-2005_con_reversed.fasta] Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency; Zrt3p [Saccharomyces cerevisiae] [nr-271106-contam.fasta] Uncharacterized protein YKL175W [nr-271106-contam.fasta] ORF [nr-271106-contam.fasta] unknown [Saccharomyces cerevisiae] [nr-271106-contam.fasta] unnamed protein product [Saccharomyces cerevisiae] [nr-271106-contam.fasta] [chemostatdb.fasta] Zinc-regulated transporter 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ZRT3 PE=1 SV=2 [UniProt_S_cerevisiae_20120516_05-16-2012_reversed.fasta] ZRT3 SGDID:S000001658, Chr XI from 118793-120304, Genome Release 64-1-1, Verified ORF, "Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency" [yeast-030211-contam.fasta] ZRT3 SGDID:S000001658, Chr XI from 118793-120304, Genome Release 64-2-1, Verified ORF, "Vacuolar membrane zinc transporter; transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency" [20141208_orf_trans.fasta] YKL175W SGDID:S000001658, Chr XI from 118793-120304, Genome Release 64-1-1, Verified ORF, "Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency" [2016-01-SGD_Yeast_Contam_Riffle_20140507-Ska-Hec-110-tubulin.fasta]
Organism:	Saccharomyces cerevisiae
Length:	503 amino acids
Gene Ontology:
Cellular Component:	vacuolar membrane [IDA]
Biological Process:	zinc ion transport [IMP][ISS] cellular zinc ion homeostasis [IMP]
Molecular Function:	zinc ion transmembrane transporter activity [IMP][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEKIPRWLLF SLISSVLCIL GALCVPLLSV AFDSKRNSQS KLVNYGLSLS AGSMITTSLY  60
   61 MLLPRIEKSN RFKVFPGLLL GICLSFFLNY LVHAFASESL VHCADSGDHA TGSHIHSKSH 120
  121 SHSHSHSHAD SHSNFSNDHD LENAPSEHGY ATSSSSVSEN DPLITKDSDR PQMKKKMSLI 180
  181 DLLTRRKSEG ECCDLNKCTP LLQSEQPEYI ACVPPVIKSS QSERNVPHGC EGSEDNGQSD 240
  241 DKDHRGLVCV ENNIGYDLEN LSLYRKNFLS SRHHHSSESP ENYGSNQLSH SFSSPLGNDV 300
  301 TENPAALADT QYHPENGSLY PHHHHLETPF SKLLSIGMQT CLVLALHKFP EGFIIFYTNR 360
  361 SDSSKSLGFS IFLSLTIHNF VEGFAMTLPF YTVFESKWVA ILITAVLGGG SQPLGALIGY 420
  421 FIFKGSTPRD HEPNMDFLLS VTAGFLLVIG LQMFQTGIGF SDGHHHHQGE GDEEMKQSHS 480
  481 SGTTCLKWCC TGVLLILASA LFT

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		BPT1 CCC1 COT1 CTR2 FTH1 PMC1 VMA9 ZRC1 ZRT3

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	VAM3	Sample: HX13 - trans-SNARE complex forms but fusion is blocked.	Hao Xu, et al. (2010)
View Run	VAM3	hx21: both fusion and trans-SNARE complex formation take place. Investigating Vam3p, Nyv1p and their partners in trans-SNARE complex	Hao Xu, et al. (2010)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	PFK1	ZRT3	1	Unpublished Fields Lab Data
View Screen	RAD6	ZRT3	1	Unpublished Fields Lab Data

Microscopy / Localization Data

New Feature: Upload Your Own Microscopy Data

	PROTEIN(S)	PUBLICATION
View Data	ZRT3	Huh WK, et al. (2003)

Protein Structure Data

[What does the above image mean?]
[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..312]	ORFEUS	12.16	RBP1
2	View Details	[313..503]	Pfam	4.283997	ZIP Zinc transporter No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2