Protein Overview: TPO5

General Information:
Name(s) found:	TPO5 / YKL174C [SGD]
Description(s) found: Found 29 descriptions. SHOW ALL	Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles [SGD]
Organism:	Saccharomyces cerevisiae
Length:	618 amino acids
Gene Ontology:
Cellular Component:	Golgi apparatus [IDA]
Biological Process:	polyamine transport [IMP]
Molecular Function:	polyamine transmembrane transporter activity [IMP][ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPEYTLLADN IRENIVHFDP NGLFDNLHTI VHEDDSQENE EAEHFNYDQV LDKSLLSRGS  60
   61 IVGLGLGLMS PVLGMCTSMA IGLINGGPLT IMLGFLISGV CIWFSSLSLG EIVSKFPMEL 120
  121 HVGSAMLAPE KLKLVCSWYT GWLMLIGNWT MSTSITFAGA QLTISLILMT NSNLISEAHL 180
  181 IFYTVIVFYL VVTVVGLVNL KFARFIETIN KVCVYWIIYA IIFIDILLLV FHKGKFRSLK 240
  241 YALFHFDNNL SGYKSAFLSF IIGFQQSNFT LQGFSMLPAL ADEVKVPEKD IPRGMSNAVL 300
  301 LSAFSGVIFL IPIMLILPDN DLLFTNHKVL PIVNIFTKST DSVVLSFFLV LLILGNLLFS 360
  361 GIGSITTSSR AVYSFSRDQA IPYYDKWTYV EPDSQSKVPK NSVVLSMIIS YFLGLLALIS 420
  421 TAAFNAFIGA AVLCLCSATF IPLVLVLFTR RRAIRSAPVK IRYKFGWFIN IVSIVWLLLS 480
  481 MVSVCLPTQV PVTFKTMNYA LMVYVFCILV ITGLYFKWGK YNFRLPLADD IKAPIPSDAE 540
  541 ETVFELEDSN VEHTLNSGTT VKESVENNSE EGFIKVHPKS STENPFEENE ENVITDYGDE 600
  601 HHTAEQEFDL ADDRRYDI

Protein Complex Data

	PUBLICATION	TOPOLOGY	COCOMPLEXED PROTEINS
View Details	Qiu et al. (2008)		GAP1 TPO5

Mass Spectrometry Data

The following runs contain data for this protein:

	BAIT	COMMENTS	PUBLICATION
View Run	ZDS1	Sample 2- cpn2 from june 2005	McCusker D, et al (2007)

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

	BAIT	PREY	HITS	PUBLICATION
View Screen	LSM2	TPO5	1	Unpublished Fields Lab Data
View Screen	CHL4	TPO5	1	Unpublished Fields Lab Data
View Screen	SCL1	TPO5	1	Unpublished Fields Lab Data
View Screen	GRR1	TPO5	1	Unpublished Fields Lab Data

Microscopy / Localization Data

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No microscopy data found in the PDR for this protein.

Protein Structure Data

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[View Top Sequence Alignments] [Show Ginzu Version Information]

Domains predicted:

#		Region(s)	Method	Confidence	Match Description
1	View Details	[1..535]	Pfam	170.823909	Amino acid permease No confident structure predictions are available.
2	View Details	[536..618]	deduced	N/A	No confident structure predictions are available.

Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076

Philius Transmembrane Prediction:

[View Details]

Source: Reynolds et al. 2008. Manuscript submitted

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2